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Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene (Q33933749)

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English	Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Kozack R

1

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Europe PubMed Central

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30 July 2017

Seo KY

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

Jelinsky SA

3

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Europe PubMed Central

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30 July 2017

Loechler EL

4

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Europe PubMed Central

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30 July 2017

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1 May 2000

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Europe PubMed Central

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30 July 2017

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Mutation Research

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Europe PubMed Central

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30 July 2017

450

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Europe PubMed Central

PubMed publication ID

30 July 2017

1-2

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Europe PubMed Central

PubMed publication ID

30 July 2017

41-59

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Europe PubMed Central

PubMed publication ID

30 July 2017

publication type of scholarly work

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Europe PubMed Central

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AP sites are not significantly involved in mutagenesis by the (+)-anti diol epoxide of benzo[a]pyrene: The complexicity of its mutagenic specificity is likely to arise from adduct conformational polymorphism

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The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide can be unstable in double-stranded DNA.

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How are potent bulky carcinogens able to induce such a diverse array of mutations?

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The Major, N2-Gua Adduct of the (+)-anti-Benzo[a]pyrene Diol Epoxide Is Capable of Inducing G.fwdarw.A and G.fwdarw.C, in Addition to G.fwdarw.T, Mutations

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The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context

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Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis

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A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G-->T versus G-->A mutations based upon a correlation between mutagenesis and molecular modeling results

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Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions

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Induction of specific frameshift and base substitution events by benzo[a]pyrene diol epoxide in excision-repair-deficient Escherichia coli

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10.1016/S0027-5107(00)00015-4

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Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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