Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner (Q33236931)

24 July 2017

Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner (English)

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24 July 2017

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Benjamin K Tsang

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author name string

Xiaojuan Yan

series ordinal

1

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24 July 2017

Michael Fraser

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2

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24 July 2017

Qing Qiu

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3

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24 July 2017

language of work or name

English

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publication date

20 March 2006

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24 July 2017

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24 July 2017

102

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24 July 2017

348-355

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24 July 2017

2

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PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.

24 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Regulation of cell death protease caspase-9 by phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Direct control of the Forkhead transcription factor AFX by protein kinase B

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Negative regulation of the forkhead transcription factor FKHR by Akt.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Cisplatin: mode of cytotoxic action and molecular basis of resistance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN, a unique tumor suppressor gene

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Integrin-linked kinase (ILK): a "hot" therapeutic target

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

p53, the cellular gatekeeper for growth and division

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Regulation of PTEN transcription by p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2005.12.033

10.1016/J.YGYNO.2005.12.033

7 January 2021

Identifiers

DOI

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24 July 2017

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