White matter hyperintensities, cognitive impairment and dementia: an update (Q30893715)

27 June 2017

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title

White matter hyperintensities, cognitive impairment and dementia: an update (English)

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27 June 2017

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cognitive dysfunction

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2

Philip Scheltens

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27 June 2017

Niels D Prins

1

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PubMed ID

25686760

27 June 2017

language of work or name

English

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publication date

17 February 2015

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27 June 2017

Nature Reviews Neurology

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27 June 2017

11

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27 June 2017

157-165

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27 June 2017

3

1 reference

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Pathogenesis of leukoaraiosis: a review

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Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence

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The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis

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Cerebral small-vessel disease and decline in information processing speed, executive function and memory.

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Silent brain infarcts and the risk of dementia and cognitive decline.

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Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

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Subcortical ischemic vascular dementia

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Dementia: Vascular and neurodegenerative pathways-will they meet?

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Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia

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21 January 2018

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Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD.

21 January 2018

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Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter?

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MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.

21 January 2018

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A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging.

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Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study

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An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases.

21 January 2018

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Automated white matter total lesion volume segmentation in diabetes.

21 January 2018

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MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements

21 January 2018

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Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

21 January 2018

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High blood pressure and cerebral white matter lesion progression in the general population

21 January 2018

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White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations

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Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study

21 January 2018

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Pathophysiology of cerebral small vessels in vascular cognitive impairment.

21 January 2018

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Subcortical ischaemic vascular dementia

21 January 2018

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Periventricular cerebral white matter lesions predict rate of cognitive decline

21 January 2018

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Decline in intelligence is associated with progression in white matter hyperintensity volume

21 January 2018

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Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy.

21 January 2018

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Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

21 January 2018

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Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

21 January 2018

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21 January 2018

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A new rating scale for age-related white matter changes applicable to MRI and CT.

21 January 2018

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Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment.

21 January 2018

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Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements.

21 January 2018

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Measuring progression of cerebral white matter lesions on MRI: visual rating and volumetrics.

21 January 2018

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A fully automated method for quantifying and localizing white matter hyperintensities on MR images

21 January 2018

1 reference

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Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression.

21 January 2018

1 reference

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FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities

21 January 2018

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Cerebral small vessel disease affects white matter microstructure in mild cognitive impairment.

21 January 2018

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Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations

21 January 2018

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Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study

21 January 2018

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Incidence of cerebral microbleeds in preclinical Alzheimer disease

21 January 2018

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Cerebral microinfarcts: the invisible lesions

21 January 2018

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Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications

21 January 2018

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Age- and sex-specific rates of leukoaraiosis in TIA and stroke patients: population-based study

21 January 2018

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Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study

21 January 2018

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Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study

21 January 2018

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White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging

21 January 2018

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The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke

21 January 2018

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Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology.

21 January 2018

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White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study.

21 January 2018

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The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review

21 January 2018

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Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

21 January 2018

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Hypertension and cerebral white matter lesions in a prospective cohort study.

21 January 2018

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Ambulatory blood pressure and the brain: a 5-year follow-up

21 January 2018

1 reference

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Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Brain imaging in type 2 diabetes

21 January 2018

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Metabolic syndrome, prediabetes, and brain abnormalities on mri in patients with manifest arterial disease: the SMART-MR study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Dysglycemia, brain volume and vascular lesions on MRI in a memory clinic population

21 January 2018

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Vascular risk factors and longitudinal changes on brain MRI: the ARIC study

21 January 2018

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Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions

21 January 2018

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Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Neuropathology of white matter changes in Alzheimer's disease and vascular dementia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments.

21 January 2018

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Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls

21 January 2018

1 reference

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White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment

21 January 2018

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Patterns of MRI lesions in CADASIL.

21 January 2018

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21 January 2018

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Two novel HTRA1 mutations in a European CARASIL patient

21 January 2018

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The genetics of small-vessel disease.

21 January 2018

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Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium

21 January 2018

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17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

21 January 2018

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Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J-SHIPP study.

21 January 2018

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Cerebral amyloid angiopathy in the elderly

21 January 2018

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Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D).

21 January 2018

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21 January 2018

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MELAS and reversible vasoconstriction of the major cerebral arteries

21 January 2018

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Executive dysfunction in subcortical ischaemic vascular disease

21 January 2018

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MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease

21 January 2018

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Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative

21 January 2018

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Brain imaging findings in elderly adults and years of life, healthy life, and able life over the ensuing 16 years: the Cardiovascular Health Study

21 January 2018

1 reference

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2001-2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease?

21 January 2018

1 reference

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Cerebral white matter lesions and the risk of dementia.

21 January 2018

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Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia

21 January 2018

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Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats.

21 January 2018

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Cognitive function, dementia and type 2 diabetes mellitus in the elderly

21 January 2018

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Homocysteine as a risk factor for cognitive impairment in stroke patients

21 January 2018

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Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

21 January 2018

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Small vessel disease and Alzheimer's dementia: pathological considerations

21 January 2018

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Pre-clinical models of human cerebral small vessel disease: utility for clinical application.

21 January 2018

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Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition

21 January 2018

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Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study

21 January 2018

1 reference

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Effect of white matter hyperintensity on medial temporal lobe atrophy in Alzheimer's disease

21 January 2018

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Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?

21 January 2018

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Subcortical vascular dementia: integrating neuropsychological and neuroradiologic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

White matter hyperintensities and cognition: testing the reserve hypothesis.

21 January 2018

1 reference

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The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases

21 January 2018

1 reference

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Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial.

21 January 2018

1 reference

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Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial

21 January 2018

1 reference

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Effect of pravastatin on cerebral infarcts and white matter lesions.

21 January 2018

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Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-a randomized clinical trial.

21 January 2018

1 reference

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Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress

21 January 2018

1 reference

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Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial

21 January 2018

1 reference

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Donepezil in vascular dementia: combined analysis of two large-scale clinical trials.

21 January 2018

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The long-term efficacy and tolerability of donepezil in patients with vascular dementia

21 January 2018

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Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial

21 January 2018

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Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

21 January 2018

1 reference

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Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

21 January 2018

1 reference

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Progression of cerebral white matter lesions in Alzheimer's disease: a new window for therapy?

21 January 2018

1 reference

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Vascular risk factors and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Aortic Atherosclerosis at Middle Age Predicts Cerebral White Matter Lesions in the Elderly

21 January 2018

1 reference

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Frequency of white matter lesions and silent lacunar infarcts.

21 January 2018

1 reference

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Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum

31 March 2020

1 reference

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Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR.

31 March 2020

1 reference

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White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home

31 March 2020

1 reference

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Periventricular venous collagenosis: association with leukoaraiosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

White matter hyperintensities are associated with amyloid burden in APOE4 non-carriers.

31 March 2020

1 reference

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Defining and categorizing leukoencephalopathies of unknown origin: MR imaging approach

31 March 2020

1 reference

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The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults

31 March 2020

1 reference

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Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on MRI: the evaluation of vascular care in Alzheimer's disease (EVA) study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.10

Vascular factors and Alzheimer disease

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25686760

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Cerebral white matter lesions in the elderly: vascular risk factors and cognitive consequences]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25686760

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25686760

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRNEUROL.2015.10

1 reference

PubMed ID

25686760

Dimensions Publication ID

27 June 2017

0 references

1 reference

PubMed ID

25686760