endoglin (Q3054016)

activin binding

1 reference

8 April 2019

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

transforming growth factor beta-activated receptor activity

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

galactose binding

1 reference

8 April 2019

Biochemical characterization of the 44G4 antigen from the HOON pre-B leukemic cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

BMP binding

1 reference

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

protein binding

6 references

8 April 2019

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

transforming growth factor beta binding

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

transmembrane signaling receptor activity

NAS

1 reference

8 April 2019

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

type II transforming growth factor beta receptor binding

NAS

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

identical protein binding

1 reference

8 April 2019

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

1 reference

8 April 2019

focal adhesion

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

receptor complex

1 reference

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

endothelial microparticle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

external side of plasma membrane

1 reference

8 April 2019

Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

1 reference

8 April 2019

focal adhesion

HDA

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

HDA

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

cell migration involved in endocardial cushion formation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

response to hypoxia

1 reference

17 October 2017

Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

regulation of transcription, DNA-templated

1 reference

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

negative regulation of nitric-oxide synthase activity

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

negative regulation of protein autophosphorylation

1 reference

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

cell motility

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

positive regulation of pathway-restricted SMAD protein phosphorylation

regulation of phosphorylation

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

extracellular matrix disassembly

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

positive regulation of systemic arterial blood pressure

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

wound healing

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

negative regulation of transcription by RNA polymerase II

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

BMP signaling pathway

1 reference

8 April 2019

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

negative regulation of pathway-restricted SMAD protein phosphorylation

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

positive regulation of angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

negative regulation of endothelial cell proliferation

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

development of the heart

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

regulation of cell adhesion

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

1 reference

8 April 2019

negative regulation of cell migration

1 reference

8 April 2019

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

regulation of cell population proliferation

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

central nervous system vasculogenesis

1 reference

8 April 2019

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of BMP signaling pathway

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

cell chemotaxis

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

transforming growth factor beta receptor signaling pathway

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

cell migration

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

detection of hypoxia

1 reference

17 October 2017

Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

regulation of transforming growth factor beta receptor signaling pathway

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

regulation of cardiac muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

bone development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

endocardial cushion to mesenchymal transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

response to corticosteroid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

extracellular matrix constituent secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

regulation of cell proliferation involved in heart morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

response to transforming growth factor beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of collagen biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

cellular response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of transcription by RNA polymerase II

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

positive regulation of protein kinase B signaling

IGI

1 reference

8 April 2019

miR-342-5p Is a Notch Downstream Molecule and Regulates Multiple Angiogenic Pathways Including Notch, Vascular Endothelial Growth Factor and Transforming Growth Factor β Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

IGI

Gene Atlas image

PBB GE ENG 201809 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

Zona pellucida domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17813

Identifiers

MeSH descriptor ID

D000071063

subject named as

Endoglin

0 references

MeSH tree code

D12.776.543.750.250

broader concept

cell surface receptor

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023