Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. (Q30336130)

19 June 2017

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title

Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. (English)

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19 June 2017

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5

Luke I Szweda

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19 June 2017

Pamela A Szweda

1

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19 June 2017

Melissa Camouse

series ordinal

2

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19 June 2017

Kathleen C Lundberg

series ordinal

3

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19 June 2017

Terry D Oberley

series ordinal

4

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19 June 2017

1 October 2003

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19 June 2017

Ageing Research Reviews

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19 June 2017

2

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19 June 2017

383-405

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19 June 2017

4

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Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

19 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Dietary self-selection can compensate an age-related decrease of rat liver 20 S proteasome activity observed with standard diet

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Oxidative Decay of DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The free radical theory of aging matures

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein oxidation in aging, disease, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11).

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Stress-inducible mechanisms of life-span extension in yeast, eubacteria and metazoans

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lipofuscin: mechanisms of age-related accumulation and influence on cell function

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Age-dependent declines in proteasome activity in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Mitochondrial free radical generation, oxidative stress, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Role of the proteasome in Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Inhibition of adenine nucleotide translocator by lipid peroxidation products

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Proteasome inactivation upon aging and on oxidation-effect of HSP 90

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Structure and functions of the 20S and 26S proteasomes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

When lysosomes get old.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Degradation of proteasomes by lysosomes in rat liver.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

IkappaB is a substrate for a selective pathway of lysosomal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Selectivity of protein oxidative damage during aging in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Degradation of oxidized proteins by the 20S proteasome.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The proteasome, a novel protease regulated by multiple mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Human hepatocellular pigments and lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Organelle-specific initiation of cell death pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Susceptibility of glucose-6-phosphate dehydrogenase modified by 4-hydroxy-2-nonenal and metal-catalyzed oxidation to proteolysis by the multicatalytic protease.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The permeability transition pore complex: another view.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Evidence that malondialdehyde-derived aminoenimine is not a fluorescent age pigment

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Structure of a Fluorescent Compound Formed from 4-Hydroxy-2-nonenal and N(alpha)-Hippuryllysine: A Model for Fluorophores Derived from Protein Modifications by Lipid Peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Detection of lipofuscin-like fluorophore in oxidized human low-density lipoprotein. 4-hydroxy-2-nonenal as a potential source of fluorescent chromophore

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Mitochondrial permeability transition and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Mitotic misregulation and human aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lectin histochemistry of lipofuscin and certain ceroid pigments

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

How the ubiquitin-proteasome system controls transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Immunolocalization of antioxidant enzymes in adult hamster kidney

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Advances in age pigment research

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Pigments in aging: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Comparative resistance of the 20S and 26S proteasome to oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein degradation and the generation of MHC class I-presented peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

4-hydroxynonenal inhibits Na(+)-K(+)-ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Proteolysis, free radicals, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Lipofuscin: mechanisms of formation and increase with age.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Proteasome inhibition enhances lipofuscin formation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

The reaction of 4-hydroxy-2-nonenal with N alpha-acetyl-L-histidine

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Mechanisms of life span determination in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Structural basis for the activation of 20S proteasomes by 11S regulators

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Oxidative damage during aging targets mitochondrial aconitase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900028-X

7 January 2021

10.1016/S1568-1637(03)00028-X

Identifiers

DOI

1 reference

19 June 2017

1 reference