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Mothers against dpp Dmel_CG12399 (Q29820402)

From Wikidata

protein found in Drosophila melanogaster

phosphorylated smad
CG12399-PB
Mothers-against-decapentaplegic
phosphoSmad
apang
CG12399 gene product from transcript CG12399-RB
mother against Dpp
Mad
Mad-PB
mothers against decapentaplegi
mother against decapentaplegic
mothers against dpp
CG12399-PA
mothers against decapentaplegic
Mad-PA
phospho-Smad

Language	Label	Description	Also known as
default for all languages	No label defined
English	Mothers against dpp Dmel_CG12399	protein found in Drosophila melanogaster	phosphorylated smad CG12399-PB Mothers-against-decapentaplegic phosphoSmad apang CG12399 gene product from transcript CG12399-RB mother against Dpp Mad Mad-PB mothers against decapentaplegi mother against decapentaplegic mothers against dpp CG12399-PA mothers against decapentaplegic Mad-PA phospho-Smad

Statements

1 reference

25 May 2022

UniProt protein ID

SMAD-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

SMAD MH1 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

SMAD/FHA domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

MAD homology, MH1, protein family

1 reference

based on heuristic

inferred from protein domain or family

SMAD domain, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAD homology 1, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

1 January 2018

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transcription coactivator activity

determination method or standard

1 reference

1 January 2018

The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

DNA-binding transcription factor activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method or standard

protein binding

determination method or standard

6 references

1 January 2018

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Drosophila TGIF proteins are transcriptional activators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

sequence-specific DNA binding

determination method or standard

3 references

1 January 2018

Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

A conserved activation element in BMP signaling during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Tgfβ signaling acts on a Hox response element to confer specificity and diversity to Hox protein function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

metal ion binding

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

determination method or standard

7 references

1 January 2018

Signal transduction of the TGF-beta superfamily by Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Nuclear interpretation of Dpp signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Identification of phosphatases for Smad in the BMP/DPP pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Fragile X mental retardation protein regulates trans-synaptic signaling inDrosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transcription regulator complex

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

determination method or standard

4 references

1 January 2018

Signal transduction of the TGF-beta superfamily by Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Identification of phosphatases for Smad in the BMP/DPP pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

biological process

compound eye morphogenesis

determination method or standard

1 reference

1 January 2018

Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

regulation of transcription by RNA polymerase II

determination method or standard

1 reference

1 January 2018

Nuclear interpretation of Dpp signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transforming growth factor beta receptor signaling pathway

determination method or standard

3 references

1 January 2018

Conservation and Divergence in Molecular Mechanisms of Axis Formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

multicellular organism development

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

determination method or standard

1 reference

1 January 2018

Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

ventral cord development

determination method or standard

1 reference

1 January 2018

Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

open tracheal system development

determination method or standard

1 reference

1 January 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

imaginal disc-derived wing morphogenesis

determination method or standard

1 reference

1 January 2018

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

imaginal disc-derived leg morphogenesis

determination method or standard

1 reference

1 January 2018

Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

histoblast morphogenesis

determination method or standard

1 reference

1 January 2018

Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

development of the heart

determination method or standard

1 reference

1 January 2018

Control of cardiac development by an evolutionarily conserved transcriptional network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

imaginal disc-derived wing vein morphogenesis

determination method or standard

1 reference

1 January 2018

Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

1 January 2018

Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

ovarian follicle cell development

determination method or standard

germ-line stem cell population maintenance

determination method or standard

1 reference

1 January 2018

decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

somatic stem cell population maintenance

determination method or standard

1 reference

1 January 2018

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

trunk segmentation

determination method or standard

1 reference

1 January 2018

Mad is required for wingless signaling in wing development and segment patterning in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

regulation of cell differentiation

determination method or standard

1 reference

1 January 2018

A transient niche regulates the specification of Drosophila intestinal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

negative regulation of salivary gland boundary specification

determination method or standard

1 reference

1 January 2018

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

positive regulation of synaptic assembly at neuromuscular junction

determination method or standard

3 references

1 January 2018

Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

4 references

1 January 2018

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Tgfβ signaling acts on a Hox response element to confer specificity and diversity to Hox protein function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

1 January 2018

Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

wing disc anterior/posterior pattern formation

determination method or standard

1 reference

1 January 2018

The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

regulation of synapse structure or activity

determination method or standard

1 reference

1 January 2018

Postsynaptic glutamate receptors regulate local BMP signaling at theDrosophilaneuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification

determination method or standard

1 reference

1 January 2018

Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

BMP signaling pathway involved in Malpighian tubule cell chemotaxis

determination method or standard

1 reference

1 January 2018

Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

negative regulation of G1/S transition of mitotic cell cycle

determination method or standard

1 reference

1 January 2018

Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42003&geneProductId=UniProtKB:P42003

determination method or standard

MAD homology, MH1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

SMAD domain, Dwarfin-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

MAD homology 1, Dwarfin-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42003

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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