Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway (Q28910446)

Ribosomal protein L5

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MDM2 proto-oncogene

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NEDD8 ligase activity

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PML regulates p53 stability by sequestering Mdm2 to the nucleolus

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H. F. Horn

1

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7 March 2017

K. H. Vousden

series ordinal

2

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7 March 2017

language of work or name

English

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publication date

2 October 2008

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7 March 2017

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7 March 2017

27

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7 March 2017

5774–5784

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7 March 2017

44

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7 March 2017

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https://api.crossref.org/works/10.1038%2FONC.2008.189

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Isolation of a 5S RNA-protein complex from mammalian ribosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Defining the molecular basis of Arf and Hdm2 interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

p53 is a general repressor of RNA polymerase III transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Tumour biology: Policing of oncogene activity by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

p53: guardian of the genome and policeman of the oncogenes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

An attempt at the identification of the proteins involved in the incorporation of 5-S RNA during 50-S ribosomal subunit assembly.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Mdm2 promotes the rapid degradation of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

On the interaction of ribosomal protein L5 with 5S rRNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Distribution of 5 s RNA in HeLa cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Regulation of p53 stability by Mdm2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Regulation of HDM2 activity by the ribosomal protein L11

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Activation of p53 by oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Ubiquitination and degradation of mutant p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

An argument for the existence of a natural complex between protein L5 and 5 S RNA in rat liver 60-S ribosomal subunits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Tumor surveillance via the ARF-p53 pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Stoichiometry, cooperativity, and stability of interactions between 5S RNA and proteins L5, L18, and L25 from the 50S ribosomal subunit of Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

5 S rRNA: structure and interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Repression of p53-mediated transcription by MDM2: a dual mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

31 March 2020

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

RNA polymerase III transcription and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.189