galactosidase alpha (Q288705)

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mammalian protein found in Homo sapiens

agalsidase alfa
Alpha-D-galactoside galactohydrolase
alpha-gal A
alpha-galactosidase A
GLA
alpha-D-galactosidase A
alpha-D-galactoside galactohydrolase 1
melibiase

Language	Label	Description	Also known as
English	galactosidase alpha	mammalian protein found in Homo sapiens	agalsidase alfa Alpha-D-galactoside galactohydrolase alpha-gal A alpha-galactosidase A GLA alpha-D-galactosidase A alpha-D-galactoside galactohydrolase 1 melibiase

Statements

1 reference

18 July 2018

UniProt protein ID

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

Glycoside hydrolase, family 27

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

Glycosyl hydrolase, all-beta

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

alpha galactosidase family

1 reference

based on heuristic

inferred from protein domain or family

Glycoside hydrolase family 27/36, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image of molecular model or crystal lattice model

PBB Protein GLA image.jpg
500 × 500; 52 KB

0 references

defined daily dose

1 milligram

route of administration

parenteral route of administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=A16AB03

1 reference

18 July 2018

UniProt protein ID

1 reference

18 July 2018

UniProt protein ID

molecular function

hydrolase activity, hydrolyzing O-glycosyl compounds

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Affinity purification of alpha-galactosidase A from human spleen, placenta, and plasma with elimination of pyrogen contamination. Properties of the purified splenic enzyme compared to other forms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

hydrolase activity, acting on glycosyl bonds

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

raffinose alpha-galactosidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

protein binding

determination method

galactoside binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

alpha-galactosidase activity

determination method

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

26 September 2017

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

26 September 2017

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

26 September 2017

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

alpha-galactosidase activity

determination method

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

alpha-galactosidase activity

determination method

6 references

8 April 2019

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

determination method

1 reference

26 September 2017

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

lysosomal lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

determination method

4 references

8 April 2019

Synthesis and processing of alpha-galactosidase A in human fibroblasts. Evidence for different mutations in Fabry disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

extracellular exosome

determination method

extracellular region

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

8 April 2019

Synthesis and processing of alpha-galactosidase A in human fibroblasts. Evidence for different mutations in Fabry disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

azurophil granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

biological process

negative regulation of nitric-oxide synthase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

glycosphingolipid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

glycosphingolipid catabolic process

determination method

1 reference

8 April 2019

Alpha-galactosidase A gene rearrangements causing Fabry disease. Identification of short direct repeats at breakpoints in an Alu-rich gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

negative regulation of nitric oxide biosynthetic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

oligosaccharide metabolic process

determination method

1 reference

26 September 2017

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

glycoside catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

carbohydrate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

determination method

oligosaccharide metabolic process

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL110458

Gene Atlas image

PBB GE GLA 214430 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P06280

1 reference

Identifiers.org

Glycoside hydrolase family 27/36, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

Alpha galactosidase A, C-terminal beta-sandwich domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06280

Identifiers

0 references

RefSeq protein ID

1 reference

18 May 2018

UniProt protein ID

1 reference

18 July 2018

UniProt protein ID

Ensembl protein ID

ENSP00000218516

1 reference

ensembl Release 93

Ensembl protein ID

ENSP00000218516

ENSP00000476935

1 reference

ensembl Release 93

Ensembl protein ID

ENSP00000476935

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(3 entries)

cywiki GLA
ttwiki GLA
ukwiki GLA

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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