FLIP and the death effector domain family (Q28297969)

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

Europe PubMed Central

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DEDD and DEDD2 associate with caspase-8/10 and signal cell death

21 April 2017

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Death Receptors: Signaling and Modulation

21 April 2017

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Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome

21 April 2017

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The three-dimensional solution structure and dynamic properties of the human FADD death domain

21 April 2017

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A unified model for apical caspase activation

21 April 2017

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 April 2017

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Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins

21 April 2017

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

21 April 2017

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PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

21 April 2017

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Insights into the regulatory mechanism for caspase-8 activation

21 April 2017

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NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

21 April 2017

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CASH, a Novel Caspase Homologue with Death Effector Domains

21 April 2017

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The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling

21 April 2017

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MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX L and initiates cell death

21 April 2017

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21 April 2017

The Hallmarks of Cancer

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NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

21 April 2017

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https://api.crossref.org/works/10.1038/ONC.2008.299

Inhibition of death receptor signals by cellular FLIP

21 April 2017

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https://api.crossref.org/works/10.1038/ONC.2008.299

The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD

21 April 2017

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https://api.crossref.org/works/10.1038/ONC.2008.299

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

CD95's deadly mission in the immune system

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

21 April 2017

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https://api.crossref.org/works/10.1038/ONC.2008.299

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

21 April 2017

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https://api.crossref.org/works/10.1038/ONC.2008.299

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

The role of c-FLIP in modulation of CD95-induced apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Casper is a FADD- and caspase-related inducer of apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.299

Molecular mechanisms of caspase regulation during apoptosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Two CD95 (APO-1/Fas) signaling pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Fas transduces activation signals in normal human T lymphocytes

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Molecular Ordering of the Initial Signaling Events of CD95

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Apoptosome: a platform for the activation of initiator caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Activation of caspases-8 and -10 by FLIP(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Interdimer processing mechanism of procaspase-8 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Live and let die: regulatory mechanisms in Fas-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

KSHV vFLIP binds to IKK-gamma to activate IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

c-FLIPR, a new regulator of death receptor-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Caspase activation is required for T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Viral FLIP enhances Wnt signaling downstream of stabilized beta-catenin, leading to control of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cell surface Death Receptor signaling in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Pathways of apoptosis in lymphocyte development, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The domains of apoptosis: a genomics perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

FADD self-association is required for stable interaction with an activated death receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Potentiation of neuroblastoma metastasis by loss of caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Apoptosis genes and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

TRAIL and apoptosis induction by TNF-family death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

An essential role for c-FLIP in the efficient development of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The complexity of TNF-related apoptosis-inducing ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Differential requirement of caspases during naive T cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The structure of FADD and its mode of interaction with procaspase-8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Fas engagement induces neurite growth through ERK activation and p35 upregulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Fas engagement accelerates liver regeneration after partial hepatectomy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

A matter of life and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299

The CD95 Receptor: Apoptosis Revisited

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.299