SCF and APC: the Yin and Yang of cell cycle regulated proteolysis (Q28294742)

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

Europe PubMed Central

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7 January 2021

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

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7 January 2021

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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7 January 2021

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

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7 January 2021

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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7 January 2021

Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae

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7 January 2021

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

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7 January 2021

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7 January 2021

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start

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7 January 2021

Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase

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7 January 2021

Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

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7 January 2021

sud1 + targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast

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7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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7 January 2021

Proteolysis and DNA Replication: The CDC34 Requirement in the Xenopus Egg Cell Cycle

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7 January 2021

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

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7 January 2021

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

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7 January 2021

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

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7 January 2021

Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation

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7 January 2021

Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression

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7 January 2021

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

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7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

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7 January 2021

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

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7 January 2021

p34Cdc28-mediated control of Cln3 cyclin degradation

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7 January 2021

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

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7 January 2021

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

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7 January 2021

G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast

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7 January 2021

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

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7 January 2021

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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7 January 2021

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

The role of beta-catenin in cell adhesion, signal transduction, and cancer

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7 January 2021

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation

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7 January 2021

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast Grr1p

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7 January 2021

COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility

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7 January 2021

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

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7 January 2021

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

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7 January 2021

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

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7 January 2021

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

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7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis

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7 January 2021

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1 reference

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7 January 2021

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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7 January 2021

Cut2 proteolysis required for sister-chromatid seperation in fission yeast

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7 January 2021

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

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7 January 2021

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

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7 January 2021

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

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7 January 2021

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

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7 January 2021

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

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7 January 2021

1 reference

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7 January 2021

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1 reference

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7 January 2021

The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis

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7 January 2021

APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle

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7 January 2021

Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis

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7 January 2021

Identification of BIME as a subunit of the anaphase-promoting complex

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7 January 2021

Binding of activated cyclosome to p13(suc1). Use for affinity purification

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7 January 2021

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

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7 January 2021

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

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7 January 2021

Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit

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7 January 2021

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

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7 January 2021

20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway

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7 January 2021

Cyclin is degraded by the ubiquitin pathway

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7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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7 January 2021

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

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7 January 2021

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

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7 January 2021

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

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7 January 2021

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1 reference

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7 January 2021

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

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7 January 2021

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

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7 January 2021

Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast

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7 January 2021

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

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7 January 2021

A WD Repeat Protein Controls the Cell Cycle and Differentiation by Negatively Regulating Cdc2/B-Type Cyclin Complexes

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7 January 2021

Fission Yeast Ste9, a Homolog of Hct1/Cdh1 and Fizzy-related, Is a Novel Negative Regulator of Cell Cycle Progression during G1-Phase

1 reference

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7 January 2021

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae

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7 January 2021

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

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7 January 2021

Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts

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7 January 2021

Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1.

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7 January 2021

Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast.

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7 January 2021

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast

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7 January 2021

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

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7 January 2021

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

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7 January 2021

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

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7 January 2021

CDC16 Controls Initiation at Chromosome Replication Origins

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7 January 2021

Is the yeast anaphase promoting complex needed to prevent re-replication during G2 and M phases?

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7 January 2021

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

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7 January 2021

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

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7 January 2021

Regulation of the Cyclin B Degradation System by an Inhibitor of Mitotic Proteolysis

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7 January 2021