The highways and byways of mRNA decay (Q28284717)

Early nonsense: mRNA decay solves a translational problem

Europe PubMed Central

cites work

1 reference

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

31 March 2020

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31 March 2020

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RNA-quality control by the exosome

31 March 2020

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P bodies: at the crossroads of post-transcriptional pathways

31 March 2020

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The AU-rich transcriptome: more than interferons and cytokines, and its role in disease.

31 March 2020

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Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

31 March 2020

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Microarray detection of novel nuclear RNA substrates for the exosome.

31 March 2020

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PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae

31 March 2020

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Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

31 March 2020

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The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae

31 March 2020

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Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae

31 March 2020

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Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding

31 March 2020

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Cap-dependent deadenylation of mRNA

31 March 2020

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Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro

31 March 2020

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The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation

31 March 2020

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Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).

31 March 2020

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The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.

31 March 2020

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Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p

31 March 2020

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A cell-free mRNA stability assay reveals conservation of the enzymes and mechanisms of mRNA decay between mosquito and mammalian cell lines

31 March 2020

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mRNA deadenylation by PARN is essential for embryogenesis in higher plants

31 March 2020

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AtPARN is an essential poly(A) ribonuclease in Arabidopsis

31 March 2020

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A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila

31 March 2020

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The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

31 March 2020

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The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

31 March 2020

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Analysis of recombinant yeast decapping enzyme

31 March 2020

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Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

31 March 2020

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Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body

31 March 2020

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Yeast Sm-like proteins function in mRNA decapping and decay

31 March 2020

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Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs

31 March 2020

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Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae

31 March 2020

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Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation

31 March 2020

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RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules

31 March 2020

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Eukaryotic Lsm proteins: lessons from bacteria

31 March 2020

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The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme

31 March 2020

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The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.

31 March 2020

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The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p

31 March 2020

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General translational repression by activators of mRNA decapping

31 March 2020

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A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

31 March 2020

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A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

31 March 2020

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Cytoplasmic foci are sites of mRNA decay in human cells

31 March 2020

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Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

31 March 2020

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A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates

31 March 2020

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SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

31 March 2020

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Targeting of aberrant mRNAs to cytoplasmic processing bodies

31 March 2020

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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

31 March 2020

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Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci.

31 March 2020

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

31 March 2020

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Processing bodies require RNA for assembly and contain nontranslating mRNAs

31 March 2020

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Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae

31 March 2020

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Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae

31 March 2020

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Relief of microRNA-mediated translational repression in human cells subjected to stress

31 March 2020

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Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies

31 March 2020

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Targeted mRNA degradation by deadenylation-independent decapping.

31 March 2020

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The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p

31 March 2020

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Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

31 March 2020

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Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

31 March 2020

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Argonaute2 is the catalytic engine of mammalian RNAi

31 March 2020

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Crystal structure of Argonaute and its implications for RISC slicer activity

31 March 2020

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A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family

31 March 2020

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Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA.

31 March 2020

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Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1.

31 March 2020

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

31 March 2020

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

31 March 2020

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Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes

31 March 2020

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RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation

31 March 2020

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A specialized processing body that is temporally and asymmetrically regulated during the cell cycle in Saccharomyces cerevisiae

31 March 2020

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Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator

31 March 2020

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Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome-bound substrate mRNA.

31 March 2020

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

31 March 2020

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Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

31 March 2020

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

31 March 2020

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A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

31 March 2020

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

31 March 2020

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Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

31 March 2020

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

31 March 2020

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An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation

31 March 2020

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Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

31 March 2020

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Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

31 March 2020

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Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

31 March 2020

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Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

31 March 2020

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Exosome-mediated recognition and degradation of mRNAs lacking a termination codon

31 March 2020

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An mRNA surveillance mechanism that eliminates transcripts lacking termination codons

31 March 2020

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Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast

31 March 2020

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Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation

31 March 2020

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Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the CGS1 gene of Arabidopsis

31 March 2020

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Global analysis of stress-regulated mRNA turnover by using cDNA arrays

31 March 2020

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Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability

31 March 2020

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A Constitutive Decay Element Promotes Tumor Necrosis Factor Alpha mRNA Degradation via an AU-Rich Element-Independent Pathway

31 March 2020

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CUG-BP binds to RNA substrates and recruits PARN deadenylase

31 March 2020

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Requirement for both EDEN and AUUUA motifs in translational arrest of Mos mRNA upon fertilization of Xenopus eggs

31 March 2020

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Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome

31 March 2020

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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

31 March 2020

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A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

31 March 2020

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Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

31 March 2020

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Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay

31 March 2020

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Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

31 March 2020

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Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) Ribonuclease

31 March 2020

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Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

31 March 2020

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Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.

31 March 2020

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p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

31 March 2020

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Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes

31 March 2020

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Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function

31 March 2020

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Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms

31 March 2020

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MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

31 March 2020

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The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

31 March 2020

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PUF proteins bind Pop2p to regulate messenger RNAs

31 March 2020

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Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast

31 March 2020

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Profiling condition-specific, genome-wide regulation of mRNA stability in yeast

31 March 2020

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Structural and functional analysis of an mRNP complex that mediates the high stability of human beta-globin mRNA

31 March 2020

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Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region

31 March 2020

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mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.

31 March 2020

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Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs

31 March 2020

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An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro

31 March 2020

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Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation

31 March 2020

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The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules

31 March 2020

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The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex

31 March 2020

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The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs

31 March 2020

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Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex and directs its posterior localization in the oocyte.

31 March 2020

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Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo

31 March 2020

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Control of translation and mRNA degradation by miRNAs and siRNAs

31 March 2020

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Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes

31 March 2020

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Ribo-gnome: the big world of small RNAs

31 March 2020

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

31 March 2020

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MicroRNAs direct rapid deadenylation of mRNA

31 March 2020

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Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

31 March 2020

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Involvement of microRNA in AU-rich element-mediated mRNA instability

31 March 2020

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Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae

31 March 2020

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A nuclear surveillance pathway for mRNAs with defective polyadenylation.

31 March 2020

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Identification of a regulated pathway for nuclear pre-mRNA turnover.

31 March 2020

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Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.

31 March 2020

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A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae

31 March 2020

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The nuclear exosome contributes to autogenous control of NAB2 mRNA levels

31 March 2020

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RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

31 March 2020

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A new yeast poly(A) polymerase complex involved in RNA quality control

31 March 2020

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Reconstitution, activities, and structure of the eukaryotic RNA exosome

31 March 2020

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