Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation (Q28270256)

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Europe PubMed Central

cites work

1 reference

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

21 April 2017

1 reference

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

21 April 2017

1 reference

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

21 April 2017

1 reference

Interleukin-21 inhibits dendritic cell activation and maturation

21 April 2017

1 reference

A critical role for IL-21 in regulating immunoglobulin production

21 April 2017

1 reference

IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells

21 April 2017

1 reference

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

21 April 2017

1 reference

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression

21 April 2017

1 reference

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 April 2017

1 reference

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

21 April 2017

1 reference

Regulatory mechanisms that determine the development and function of plasma cells

21 April 2017

1 reference

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

21 April 2017

1 reference

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

21 April 2017

1 reference

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

21 April 2017

1 reference

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

21 April 2017

1 reference

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

21 April 2017

1 reference

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

21 April 2017

1 reference

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

21 April 2017

1 reference

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 April 2017

1 reference

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 April 2017

1 reference

21 April 2017

1 reference

Cytokines and immunodeficiency diseases

21 April 2017

1 reference

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

21 January 2018

1 reference

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

21 January 2018

1 reference

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

1 reference

The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

21 January 2018

2 references

21 January 2018

inferred from DOI database lookup

7 January 2021

based on heuristic

Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses

1 reference

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

21 January 2018

1 reference

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

21 January 2018

1 reference

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

21 January 2018

1 reference

An interleukin-4-induced transcription factor: IL-4 Stat

21 January 2018

1 reference

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

21 January 2018

1 reference

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

21 January 2018

1 reference

STAT-1: a novel regulator of apoptosis

21 January 2018

1 reference

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

1 reference

The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

1 reference

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis

21 January 2018

1 reference

Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo

21 January 2018

1 reference

Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis

21 January 2018

1 reference

Differentiation of human gamma-delta T cells towards distinct memory phenotypes

21 January 2018

1 reference

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

21 January 2018

1 reference

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

21 January 2018

1 reference

Calcium-dependent activation of interleukin-21 gene expression in T cells

21 January 2018

1 reference

Generation and analysis of interleukin-4 deficient mice

21 January 2018

1 reference

Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts

21 January 2018

1 reference

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells

21 January 2018

1 reference

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression

21 January 2018

1 reference

Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells

21 January 2018

1 reference

The multi-subunit interleukin-2 receptor

21 January 2018

1 reference

Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency

21 January 2018

1 reference

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

21 January 2018

1 reference

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

21 January 2018

1 reference

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

21 January 2018

1 reference

Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

21 January 2018

1 reference

A y chromosome associated factor in strain bxsb producing accelerated autoimmunity and lymphoproliferation

21 January 2018

1 reference

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

21 January 2018

1 reference

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

21 January 2018

1 reference

Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo

21 January 2018

1 reference

Cytokine requirements for the growth and development of mouse NK cells in vitro

21 January 2018

1 reference

IL-21 induces the functional maturation of murine NK cells

21 January 2018

1 reference

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

21 January 2018

1 reference

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

21 January 2018

1 reference

In vivo and in vitro roles of IL-21 in inflammation.

21 January 2018

1 reference

The NOD mouse: a model of immune dysregulation

21 January 2018

1 reference

Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene

21 January 2018

1 reference

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

21 January 2018

1 reference

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

21 January 2018

1 reference

Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts

21 January 2018

1 reference

Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects

21 January 2018

1 reference

IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma

21 January 2018

1 reference

IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice

21 January 2018

1 reference

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

21 January 2018

1 reference

Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma.

21 January 2018

1 reference

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

21 January 2018

1 reference

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

1 reference

IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development

21 January 2018

1 reference

Impaired development of Th2 cells in IL-13-deficient mice.

21 January 2018

1 reference

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

21 January 2018

1 reference

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

1 reference

Immune responses in interleukin-2-deficient mice

21 January 2018

1 reference

Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes

21 January 2018

1 reference

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

31 March 2020

1 reference

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

31 March 2020

1 reference

IL-21 induces the apoptosis of resting and activated primary B cells

31 March 2020

1 reference

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

31 March 2020

1 reference

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

31 March 2020

1 reference

Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen

31 March 2020

1 reference

Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis

31 March 2020

1 reference

Human IL-2 receptor alpha chain deficiency

31 March 2020

1 reference