Update on colchicine and its mechanism of action (Q28217460)

Current Rheumatology Reports

Europe PubMed Central

title

Update on colchicine and its mechanism of action (English)

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Yair Molad

1

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language of work or name

English

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publication date

June 2002

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published in

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volume

4

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page(s)

252-6

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issue

3

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exact match

https://scigraph.springernature.com/pub.10.1007/s11926-002-0073-2

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cites work

Oral absorption characteristics and pharmacokinetics of colchicine in healthy volunteers after single and multiple doses

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Response of microtubules to the addition of colchicine and tubulin-colchicine: evaluation of models for the interaction of drugs with microtubules

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Effect of colchicine on polymorphonuclear leucocyte chemotaxis in human volunteers

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The adhesion molecules of inflammation.

21 January 2018

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Involvement of secretory phospholipase A2 activity in the zymosan rat air pouch model of inflammation

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Does colchicine work? The results of the first controlled study in acute gout.

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The management of gout

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12 December 2020

Role of microtubules in the phasic pattern of insulin release

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Colchicine disposition in patients with familial Mediterranean fever with renal impairment.

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Histamine release from human leukocytes: studies with deuterium oxide, colchicine, and cytochalasin B

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Colchicine in acute gout. Reassessment of risks and benefits

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Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects

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Mobilization and extracellular release of granular enzymes from human leukocytes during phagocytosis: inhibition by colchicine and cortisol but not by salicylate

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Pathogenesis of crystal-induced inflammation

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Histamine release from rat peritoneal mast cells: inhibition by colchicine and potentiation by deuterium oxide.

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Colchicine. Clinical pharmacology in acute gouty arthritis

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The action of colchicine in acute gouty arthritis

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Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils

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Plasma levels of colchicine after oral administration of a single dose

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Brief report: treatment of severe colchicine overdose with colchicine-specific Fab fragments

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Crystal-neutrophil interactions lead to interleukin-1 synthesis

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Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expr

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Inhibition of LPS-induced tumor necrosis factor-alpha production by colchicine and other microtubule disrupting drugs

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History of the use of colchicum and related medicaments in gout; with suggestions for further research

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Colchicine inhibits ionophore-induced formation of leukotriene B4 by human neutrophils: the role of microtubules

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Crystal-induced neutrophil activation. IV. Specific inhibition of tyrosine phosphorylation by colchicine.

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Inhibition of delayed hypersensitivity reactions in mice by colchicine. I. Mechanism of inhibition of contact sensitivity in vivo

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Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution

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12 December 2020

Colchicine plasma levels. Implications as to pharmacology and mechanism of action

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Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes

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Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine

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Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents

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Molecular mechanism of colchicine action: induced local unfolding of beta-tubulin

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A quantitative ultrastructural study of microtubule content and secretory granule accumulation in parathyroid glands of phosphate- and colchicine-treated rats

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Prophylactic colchicine therapy of intercritical gout. A placebo-controlled study of probenecid-treated patients

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Review: systemic toxicity associated with the intravenous administration of colchicine--guidelines for use.

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Colchicine disposition in human leukocytes after single and multiple oral administration

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Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate

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Colchicine: 1998 update.

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Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages.

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12 December 2020

Binding of colchicine and thiocolchicoside to human serum proteins and blood cells.

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12 December 2020

Colchicine induces apoptosis in cerebellar granule cells

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12 December 2020

Colchicine and methotrexate reduce leukocyte adherence and emigration in rat mesenteric venules

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12 December 2020

Paradoxical effects of colchicine on the activation of human neutrophilis by chemotactic factors and inflammatory microcrystal

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12 December 2020

Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation

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12 December 2020

Prolonged reduction in polymorphonuclear adhesion following oral colchicine.

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12 December 2020

Human polymorphonuclear leukocytes: demonstration of microtubules and effect of colchicine

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12 December 2020

Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects

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12 December 2020