S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease (Q28116512)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990442

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

GOA release 2020-03-11

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3

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Eliezer Masliah

8

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author name string

Carmen R. Sunico

1

1 reference

4 January 2017

Tomohiro Nakamura

2

1 reference

4 January 2017

Michael Mante

4

1 reference

4 January 2017

Anthony Adame

5

1 reference

4 January 2017

Shing Fai Chan

6

1 reference

4 January 2017

Traci Fang Newmeyer

7

1 reference

4 January 2017

Nobuki Nakanishi

9

1 reference

4 January 2017

Stuart A. Lipton

Molecular Neurodegeneration

10

1 reference

4 January 2017

28 August 2013

1 reference

4 January 2017

1 reference

4 January 2017

8

1 reference

4 January 2017

29

1 reference

4 January 2017

https://scigraph.springernature.com/pub.10.1186/1750-1326-8-29

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cites work

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Oxidative stress in Parkinson's disease

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Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

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29 September 2017

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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

29 September 2017

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

29 September 2017

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Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action

29 September 2017

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Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

29 September 2017

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Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?

29 September 2017

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Gene-environment interactions in Parkinson's disease and other forms of parkinsonism

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

29 September 2017

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Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California

29 September 2017

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TRPC1 regulates skeletal myoblast migration and differentiation

29 September 2017

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The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis

29 September 2017

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Apoptotic neuronal death in Parkinson's disease: involvement of nitric oxide

29 September 2017

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Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model

29 September 2017

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Role of nitric oxide in Parkinson's disease

29 September 2017

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Nitric oxide and neurological disorders

29 September 2017

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Parkin-associated Parkinson's disease

29 September 2017

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

29 September 2017

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

29 September 2017

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Dopamine depletion impairs precursor cell proliferation in Parkinson disease.

29 September 2017

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Nitric oxide negatively regulates mammalian adult neurogenesis

29 September 2017

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Are ubiquitination pathways central to Parkinson's disease?

29 September 2017

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Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype

29 September 2017

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Parkinson's disease: current and future challenges

29 September 2017

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p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

29 September 2017

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Transcription factors p53 and HIF-1alpha as targets of nitric oxide

29 September 2017

1 reference

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The role of p53 in neuronal cell death

29 September 2017

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The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.

29 September 2017

1 reference

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Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

29 September 2017

1 reference

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Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Polymorphonuclear leukocyte nitrite content and antioxidant enzymes in Parkinson's disease patients.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

2 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Environmental risk factors and Parkinson's disease: a case-control study in Taiwan

21 January 2018

1 reference

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Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats

21 January 2018

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https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease

21 January 2018

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Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation.

21 January 2018

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Nitric oxide-mediated inhibition of Hdm2-p53 binding

21 January 2018

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https://api.crossref.org/works/10.1186%2F1750-1326-8-29

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells.

21 January 2018

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A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-29

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-29

Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Understanding cell death in Parkinson's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3765907

Parkin: a multipurpose neuroprotective agent?

27 November 2018

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12 December 2020

Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate)

1 reference

12 December 2020

Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease

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12 December 2020

Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease?

1 reference

12 December 2020

The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993

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12 December 2020

P53- and CD95-associated apoptosis in neurodegenerative diseases

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12 December 2020

Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway

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12 December 2020