HRD4/NPL4Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins (Q27939971)

1 December 2016

title

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins (English)

1 reference

1 December 2016

HRD4/NPL4Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins (English)

1 reference

Crossref

DOI

10.1091/MBC.12.12.4114

https://api.crossref.org/works/10.1091/MBC.12.12.4114

AAA family ATPase CDC48 YDL126C

1 February 2025

main subject

1 reference

Polyubiquitin-binding protein UFD1 YGR048W

GOA release 2020-03-11

1 reference

Nuclear protein localization protein 4 YBR170C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

N. W. Bays

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

1 February 2025

S. K. Wilhovsky

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

1 February 2025

A. Goradia

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

1 February 2025

K. Hodgkiss-Harlow

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

1 February 2025

R. Y. Hampton

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

https://europepmc.org/articles/pmc60780?pdf=render

1 February 2025

publication date

December 2001

0 references

language of work or name

English

0 references

work available at URL

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

https://europepmc.org/articles/PMC60780

1 February 2025

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

https://europepmc.org/articles/PMC60780?pdf=render

1 February 2025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A11739805

Molecular Biology of the Cell

1 February 2025

published in

1 reference

The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

1 December 2016

volume

12

0 references

issue

12

0 references

page(s)

4114-28

0 references

cites work

1 reference

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

20 March 2017

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

20 March 2017

1 reference

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The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex

20 March 2017

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20 March 2017

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

20 March 2017

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A regulatory link between ER-associated protein degradation and the unfolded-protein response

20 March 2017

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

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Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures

20 March 2017

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

20 March 2017

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MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae

20 March 2017

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Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

20 March 2017

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Ero1p: A Novel and Ubiquitous Protein with an Essential Role in Oxidative Protein Folding in the Endoplasmic Reticulum

20 March 2017

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The regulatory particle of the Saccharomyces cerevisiae proteasome.

20 March 2017

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Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

20 March 2017

1 reference

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The N-end rule: functions, mysteries, uses

20 March 2017

1 reference

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CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p

20 March 2017

1 reference

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

20 March 2017

1 reference

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cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11

20 March 2017

1 reference

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A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

20 March 2017

1 reference

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Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

20 March 2017

1 reference

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A proteolytic pathway that recognizes ubiquitin as a degradation signal

20 March 2017

1 reference

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The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo

20 March 2017

1 reference

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Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

20 March 2017

1 reference

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Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies

20 March 2017

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The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene.

20 March 2017

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A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

20 March 2017

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20 March 2017

1 reference

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

20 March 2017

1 reference

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A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic

20 March 2017

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

7 April 2017

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The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control

29 September 2017

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Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p

29 September 2017

1 reference

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HRD gene dependence of endoplasmic reticulum-associated degradation

29 September 2017

1 reference

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ER protein quality control and proteasome-mediated protein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Posttranslational quality control: folding, refolding, and degrading proteins.

29 September 2017

1 reference

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The AAA team: related ATPases with diverse functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.

29 September 2017

1 reference

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The endoplasmic reticulum as a site of protein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

29 September 2017

1 reference

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Quality control in the secretory pathway

29 September 2017

1 reference

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A role for unsaturated fatty acids in mitochondrial movement and inheritance

29 September 2017

1 reference

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The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo

29 September 2017

1 reference

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Measuring protein degradation with green fluorescent protein

29 September 2017

1 reference

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A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

2 June 2018

1 reference

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The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

The unfolded protein response: an intracellular signalling pathway with many surprising features

2 June 2018

1 reference

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Isolation and characterization of two 20S proteasomes from the endoplasmic reticulum of rat liver microsomes

27 November 2018

1 reference

12 December 2020

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

1 reference

12 December 2020

Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver

1 reference

12 December 2020

Enhancement of immunoblot sensitivity by heating of hydrated filters

1 reference

12 December 2020

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1 reference

12 December 2020

PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core

1 reference

12 December 2020

Journal of Biological Chemistry

46

4

4

Strawn L.A.

2000

1 reference

Crossref

DOI

10.1091/MBC.12.12.4114

https://api.crossref.org/works/10.1091/MBC.12.12.4114

1 February 2025

Identifiers

DOI

10.1091/MBC.12.12.4114

1 reference

1 reference

1 reference

1 reference