Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family (Q27746503)

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7 November 2019

title

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family (English)

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7 November 2019

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1

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7 November 2019

Naoki Kunishima

2

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7 November 2019

author name string

N Inohara

3

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7 November 2019

Y Ishibashi

4

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7 November 2019

S Ohta

5

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7 November 2019

K Morikawa

6

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publication date

1 October 1997

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Journal of Biological Chemistry

7 November 2019

language of work or name

English

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published in

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7 November 2019

volume

272

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7 November 2019

issue

44

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7 November 2019

page(s)

27886-27892

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Molecular regulation of apoptosis: genetic controls on cell death.

7 November 2019

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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Bcl-2 and the regulation of programmed cell death

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

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An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells

21 January 2018

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harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

21 January 2018

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Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis

21 January 2018

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Structure—Function Analysis of Bcl-2 Family Proteins

21 January 2018

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

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Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

21 January 2018

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Interaction and regulation of subcellular localization of CED-4 by CED-9

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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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Bax-independent inhibition of apoptosis by Bcl-XL.

21 January 2018

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Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

21 January 2018

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Mechanisms and genes of cellular suicide

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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Bcl-x(L) forms an ion channel in synthetic lipid membranes

21 January 2018

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Role of peptide conformation in the rate and mechanism of deamidation of asparaginyl residues

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

21 January 2018

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Stabilization of Escherichia coli ribonuclease HI by cavity-filling mutations within a hydrophobic core

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

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Protein structure comparison by alignment of distance matrices

21 January 2018

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Molecular aging of tubulin: accumulation of isoaspartyl sites in vitro and in vivo

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Immunochemical and immunohistochemical localization of Bcl-x protein in the rat central nervous system

21 January 2018

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Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein

21 January 2018

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A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1

21 January 2018

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BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

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Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

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Structure of the membrane-pore-forming fragment of colicin A

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.272.44.27886

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9346936%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference