Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid (Q27733135)

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M A Fleming

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O Futer

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S A Raybuck

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S P Chambers

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P R Caron

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K P Wilson

Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation

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publication date

14 June 1996

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language of work or name

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85

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issue

6

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page(s)

921-30

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cites work

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7 January 2021

Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil

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7 January 2021

Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12

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Probing the active site of human IMP dehydrogenase using halogenated purine riboside 5'-monophosphates and covalent modification reagents

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7 January 2021

Divergent evolution of a beta/alpha-barrel subclass: detection of numerous phosphate-binding sites by motif search

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7 January 2021

A simple method for the rapid determination of the stereospecificity of NAD-dependent dehydrogenases applied to mammalian IMP dehydrogenase and bacterial NADH peroxidase

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Inhibition of IMPDH by mycophenolic acid: dissection of forward and reverse pathways using capillary electrophoresis

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The inhibition of nucleic acid synthesis by mycophenolic acid

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Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity

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Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding

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7 January 2021

Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism

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7 January 2021

The FSSP database: fold classification based on structure-structure alignment of proteins

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7 January 2021

Human IMP dehydrogenase. Kinetics and regulatory properties

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Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus.

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IMP dehydrogenase, an enzyme linked with proliferation and malignancy

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

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7 January 2021

Nuclear magnetic resonance and molecular modeling study on mycophenolic acid: implications for binding to inosine monophosphate dehydrogenase

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7 January 2021

Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells

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7 January 2021

Human type I and II IMP dehydrogenases as drug targets

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Improved Fourier coefficients for maps using phases from partial structures with errors

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Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement

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Tissue-differential expression of two distinct genes for human IMP dehydrogenase (E.C.1.1.1.205).

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Mycophenolate mofetil: a report of the consensus panel.

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Inhibition of purine metabolism—Computer- assisted analysis of drug effects

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Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate

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7 January 2021

Monovalent cation activation and kinetic mechanism of inosine 5'-monophosphate dehydrogenase

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