Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases (Q27629650)

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R A Powers

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L C Blasczcak

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C Y Wu

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F Prati

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B K Shoichet

The crisis in antibiotic resistance

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language of work or name

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January 2001

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published in

Chemistry and Biology

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volume

8

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page(s)

17-31

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issue

1

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cites work

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A rapid-kinetic study of the class C beta-lactamase of Enterobacter cloacae 908R

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The diversity of the catalytic properties of class A beta-lactamases

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The enigmatic catalytic mechanism of active-site serine beta-lactamases

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Functional analyses of AmpC beta-lactamase through differential stability

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The inhibition of class C beta-lactamases by boronic acids

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Beta-lactamase inhibitors. The inhibition of serine beta-lactamases by specific boronic acids

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Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase

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Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

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Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design

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The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamase

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Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)

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PROCHECK: a program to check the stereochemical quality of protein structures

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Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog

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Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis

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Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

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7 January 2021

Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids

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Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis

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A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.

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Role of asparagine 152 in catalysis of beta-lactam hydrolysis by Escherichia coli AmpC beta-lactamase studied by site-directed mutagenesis.

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The importance of the negative charge of beta-lactam compounds in the interactions with active-site serine DD-peptidases and beta-lactamases

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A quick method for the determination of inhibition constants

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Structure of the extended-spectrum class C beta-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion

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Synthesis and properties of pinanediol .alpha.-amido boronic esters

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Kinetic and thermodynamic consequences of the removal of the Cys-77-Cys-123 disulphide bond for the folding of TEM-1 beta-lactamase

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7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Improved methods for building protein models in electron density maps and the location of errors in these models

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