NAD-dependent histone deacetylase SIR2 YDL042C (Q27551037)

DHS-like NAD/FAD-binding domain superfamily

1 reference

Sirtuin, catalytic core small domain superfamily

1 reference

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NAD-dependent histone deacetylase Sir2, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

NAD-dependent histone deacetylase activity (H4-K16 specific)

1 reference

14 February 2019

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD-dependent histone deacetylase activity (H3-K9 specific)

1 reference

9 May 2019

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

1 reference

9 May 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

1 reference

9 May 2019

NAD-dependent histone deacetylase activity (H3-K14 specific)

1 reference

9 May 2019

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

nucleosome binding

1 reference

9 May 2019

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD+ binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06700&geneProductId=UniProtKB:P06700

1 reference

27 March 2018

protein binding

7 references

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Defining the budding yeast chromatin‐associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

The glucanosyltransferase Gas1 functions in transcriptional silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD-dependent histone deacetylase activity

1 reference

27 March 2018

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06700&geneProductId=UniProtKB:P06700

NAD-dependent histone deacetylase activity

nucleosome binding

NAD-dependent histone deacetylase activity (H3-K14 specific)

histone deacetylase activity (H4-K16 specific)

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD-independent histone deacetylase activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD-dependent histone deacetylase activity (H3-K9 specific)

NAD-dependent histone deacetylase activity (H4-K16 specific)

chromatin silencing complex

cell component

1 reference

27 March 2018

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06700&geneProductId=UniProtKB:P06700

RENT complex

1 reference

9 May 2019

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

1 reference

9 May 2019

chromatin silencing complex

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

3 references

9 May 2019

9 May 2019

Localization of Sir2p: the nucleolus as a compartment for silent information regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

Set3 complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

negative regulation of DNA replication

biological process

1 reference

9 May 2019

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

silent mating-type cassette heterochromatin assembly

2 references

9 May 2019

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

9 May 2019

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

1 reference

9 May 2019

rDNA heterochromatin assembly

1 reference

9 May 2019

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

negative regulation of DNA recombination

transcription, DNA-templated

IGI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06700&geneProductId=UniProtKB:P06700

1 reference

27 March 2018

negative regulation of DNA amplification

1 reference

9 May 2019

Regulation of ribosomal DNA amplification by the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

1 reference

9 May 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06700&geneProductId=UniProtKB:P06700

1 reference

27 March 2018

sister chromatid cohesion

1 reference

9 May 2019

Determinants of Sir2-Mediated, Silent Chromatin Cohesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

histone deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

telomere tethering at nuclear periphery

1 reference

9 May 2019

Quiescent Saccharomyces cerevisiae forms telomere hyperclusters at the nuclear membrane vicinity through a multifaceted mechanism involving Esc1, the Sir complex, and chromatin condensation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

histone H3-K9 modification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

histone H3 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

histone H4 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

histone H3-K9 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

double-strand break repair via nonhomologous end joining

1 reference

9 May 2019

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

establishment of protein-containing complex localization to telomere

1 reference

9 May 2019

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06700

NAD-dependent histone deacetylase Sir2, N-terminal

has part(s)

1 reference

Sirtuin family, catalytic core domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference