NEDD4 family E3 ubiquitin-protein ligase YER125W (Q27547704)

WW domain superfamily

1 reference

C2 domain superfamily

1 reference

E3 ubiquitin-protein ligase, SMURF1 type

1 reference

P-P-bond-hydrolysis-driven transporter

1 reference

3.A.31.1.1

2 October 2019

hierarchical database ID heuristic

auxiliary protein involved in transmembrane transport

1 reference

8.A.30.1.4

2 October 2019

hierarchical database ID heuristic

ESCRT-III family

1 reference

3.A.31.1.1

2 October 2019

hierarchical database ID heuristic

HECT domain, protein family

1 reference

inferred from protein domain or family

C2 domain, protein family

1 reference

inferred from protein domain or family

WW domain, protein family

1 reference

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

ubiquitin-protein transferase activity

A bacterial genetic selection system for ubiquitylation cascade discovery

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

9 May 2019

A bacterial genetic selection system for ubiquitylation cascade discovery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ubiquitin binding

1 reference

9 May 2019

Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

phosphatidylinositol binding

1 reference

9 May 2019

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

protein binding

11 references

9 May 2019

Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Transferrin receptor-like proteins control the degradation of a yeast metal transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

A comprehensive two-hybrid analysis to explore the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

A global protein kinase and phosphatase interaction network in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

1 reference

9 May 2019

ubiquitin protein ligase activity

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

4 references

9 May 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

9 May 2019

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

cell component

Golgi apparatus

1 reference

9 May 2019

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

extrinsic component of cytoplasmic side of plasma membrane

1 reference

9 May 2019

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

cellular bud tip

1 reference

9 May 2019

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

3 references

16 July 2018

16 July 2018

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

16 July 2018

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

endosome membrane

1 reference

9 May 2019

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

1 reference

9 May 2019

actin cortical patch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

1 reference

9 May 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

4 references

9 May 2019

9 May 2019

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

mitochondrion

3 references

9 May 2019

Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The proteome of Saccharomyces cerevisiae mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

plasma membrane

1 reference

9 May 2019

The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

biological process

cellular response to UV

1 reference

9 May 2019

Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of fatty acid biosynthetic process

1 reference

9 May 2019

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

The ESCRT-III Adaptor Protein Bro1 Controls Functions of Regulator for Free Ubiquitin Chains 1 (Rfu1) in Ubiquitin Homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of actin cytoskeleton organization

1 reference

9 May 2019

Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ubiquitin-dependent endocytosis

1 reference

9 May 2019

GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of dolichol biosynthetic process

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of endocytosis

1 reference

9 May 2019

Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of tRNA export from nucleus

1 reference

9 May 2019

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

protein autoubiquitination

1 reference

9 May 2019

Ubp2 Regulates Rsp5 Ubiquitination Activity In Vivo and In Vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of receptor-mediated endocytosis

1 reference

9 May 2019

Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

protein polyubiquitination

regulation of ergosterol biosynthetic process

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of tRNA processing

1 reference

9 May 2019

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of rRNA processing

1 reference

9 May 2019

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of initiation of mating projection growth

1 reference

9 May 2019

Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

1 reference

9 May 2019

GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of ubiquinone biosynthetic process

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of multivesicular body size

1 reference

9 May 2019

Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

late endosome to vacuole transport via multivesicular body sorting pathway

regulation of ribosomal large subunit export from nucleus

1 reference

9 May 2019

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of protein localization

protein monoubiquitination

G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

16 July 2018

The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

regulation of phosphate metabolic process

1 reference

9 May 2019

The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ribophagy

1 reference

9 May 2019

Is the Rsp5 ubiquitin ligase involved in the regulation of ribophagy?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

regulation of nitrogen utilization

1 reference

9 May 2019

NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

poly(A)+ mRNA export from nucleus

1 reference

9 May 2019

Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

mitochondria-associated ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ubiquitin-dependent protein catabolic process

Nitrogen-regulated Ubiquitination of the Gap1 Permease ofSaccharomyces cerevisiae

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

16 July 2018

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

16 July 2018

16 July 2018

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

protein ubiquitination

Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

16 July 2018

16 July 2018

SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39940&geneProductId=UniProtKB:P39940

protein polyubiquitination

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

ubiquitin-dependent protein catabolic process

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Nitrogen-regulated Ubiquitination of the Gap1 Permease ofSaccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

9 May 2019

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

protein ubiquitination

Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

9 May 2019

SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

positive regulation of protein catabolic process

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39940

1 reference

C2 domain

1 reference

WW domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

20 March 2022

3.A.31.1.1

1 reference

Transporter Classification database