Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1 (Q26795679)

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1 June 2020

author name string

Michael Y Choi

1

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1 June 2020

George F Widhopf

2

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1 June 2020

Christina C N Wu

3

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1 June 2020

Fitzgerald Lao

5

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1 June 2020

Anil Sadarangani

6

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1 June 2020

Joy Cavagnaro

7

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1 June 2020

Charles Prussak

8

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Dennis A Carson

9

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Catriona Jamieson

10

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1 June 2020

Thomas J Kipps

11

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Clinical Lymphoma, Myeloma & Leukemia

1 June 2020

language of work or name

English

0 references

publication date

June 2015

0 references

published in

1 reference

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1 June 2020

volume

15 Suppl

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1 June 2020

page(s)

S167-9

1 reference

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Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

1 June 2020

cites work

1 reference

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

7 April 2017

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A novel family of cell surface receptors with tyrosine kinase-like domain

7 April 2017

1 reference

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The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction

7 April 2017

1 reference

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Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies

7 April 2017

1 reference

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Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy

7 April 2017

1 reference

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Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells

28 September 2017

1 reference

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Current and emerging monoclonal antibody treatments for chronic lymphocytic leukemia: state of the art.

28 September 2017

1 reference

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ROR1 expression correlated with poor clinical outcome in human ovarian cancer

28 September 2017

1 reference

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Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548279

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548279

Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.

28 September 2017

1 reference

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The onco-embryonic antigen ROR1 is expressed by a variety of human cancers

28 September 2017

1 reference

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Targeting malignant B cells with an immunotoxin against ROR1

28 September 2017

1 reference

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ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth

28 September 2017

1 reference

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ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia

28 September 2017

1 reference

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Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis

28 September 2017

1 reference

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Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

28 September 2017

1 reference

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The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548279

Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans

28 September 2017

1 reference

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

28 September 2017

1 reference

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The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

28 September 2017

1 reference

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Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

31 May 2018

1 reference

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Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells.

28 November 2018

1 reference

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10.1016/J.CLML.2015.02.010

28 November 2018

Identifiers

DOI

2 references

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1 June 2020

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1 June 2020

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