Two faces of p53: aging and tumor suppression (Q24681014)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Two faces of p53: aging and tumor suppression (English)

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9 January 2020

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20 December 2019

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24 January 2021

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8 February 2021

Dipa Bhaumik

3

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9 January 2020

publication date

16 October 2007

10 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

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9 January 2020

24 January 2021

8 February 2021

31 July 2022

language of work or name

English

0 references

published in

Nucleic Acids Research

10 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

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24 January 2021

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31 July 2022

35

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issue

22

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9 January 2020

page(s)

7475-7484

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Creative Commons Attribution-NonCommercial

9 January 2020

copyright license

9 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

24 January 2021

8 February 2021

31 July 2022

publication type of scholarly work

review article

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on focus list of Wikimedia project

8 February 2021

31 July 2022

ScienceSource

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cites work

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Deletion of Ku86 causes early onset of senescence in mice

7 April 2017

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Premature aging in mice deficient in DNA repair and transcription

7 April 2017

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Genomic instability in mice lacking histone H2AX

7 April 2017

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Mitochondria, oxidants, and aging

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 April 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

7 April 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

7 April 2017

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

7 April 2017

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The antioxidant function of the p53 tumor suppressor

7 April 2017

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

7 April 2017

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A DNA damage checkpoint response in telomere-initiated senescence

7 April 2017

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Extended longevity in mice lacking the insulin receptor in adipose tissue

7 April 2017

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

7 April 2017

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p53 is required for radiation-induced apoptosis in mouse thymocytes

7 April 2017

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

7 April 2017

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 April 2017

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7 April 2017

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Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population

7 April 2017

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Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

28 September 2017

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Loss of stem cell regenerative capacity within aged niches

28 September 2017

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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

28 September 2017

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

28 September 2017

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p53 and metabolism: Inside the TIGAR.

28 September 2017

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Increased cell-to-cell variation in gene expression in ageing mouse heart

28 September 2017

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ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

28 September 2017

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The complexity of p53 stabilization and activation

28 September 2017

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Increased p53 activity does not accelerate telomere-driven ageing

28 September 2017

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Tumor suppression by p53 without accelerated aging: just enough of a good thing?

28 September 2017

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Tumor suppression and normal aging in mice with constitutively high p53 activity

28 September 2017

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Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

28 September 2017

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The role of the BRCA1 tumor suppressor in DNA double-strand break repair

28 September 2017

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

28 September 2017

1 reference

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Human cell senescence as a DNA damage response.

28 September 2017

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The role of oxidative damage and stress in aging.

28 September 2017

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The cellular response to general and programmed DNA double strand breaks

28 September 2017

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Functional aging and gradual senescence in zebrafish

28 September 2017

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Initiating cellular stress responses

28 September 2017

1 reference

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p53 moves to mitochondria: a turn on the path to apoptosis.

28 September 2017

1 reference

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Modulation of mammalian life span by the short isoform of p53.

28 September 2017

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

28 September 2017

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

28 September 2017

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Cancer and ageing: rival demons?

28 September 2017

1 reference

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Decision making by p53: life, death and cancer

28 September 2017

1 reference

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Transcriptional repression mediated by the p53 tumour suppressor

28 September 2017

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

28 September 2017

1 reference

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

28 September 2017

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

28 September 2017

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Dying of old age: an examination of death certificates of Minnesota centenarians

28 September 2017

1 reference

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

28 September 2017

1 reference

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Large genome rearrangements as a primary cause of aging

28 September 2017

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Genotoxic and non-genotoxic pathways of p53 induction

28 September 2017

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Disease model: human aging

28 September 2017

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28 September 2017

1 reference

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

28 September 2017

1 reference

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Analysis of ku80-mutant mice and cells with deficient levels of p53

28 September 2017

1 reference

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

28 September 2017

1 reference

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Primary structure polymorphism at amino acid residue 72 of human p53.

28 September 2017

1 reference

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Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

28 September 2017

1 reference

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

28 September 2017

1 reference

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Total body irradiation selectively induces murine hematopoietic stem cell senescence

30 May 2018

1 reference

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Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling

30 May 2018

1 reference

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Role of DNA-dependent protein kinase in neuronal survival.

30 May 2018

1 reference

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Delayed ageing through damage protection by the Arf/p53 pathway

30 May 2018

1 reference

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

28 November 2018

1 reference

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

28 November 2018

1 reference

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Cellular senescence in aging primates

28 November 2018

1 reference

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Complicating the role of p53 in aging

28 November 2018

1 reference

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Temporal dissection of p53 function in vitro and in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

28 November 2018

1 reference

12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

12 December 2020

Cancer and ageing: a nexus at several levels

1 reference

12 December 2020

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKM744

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942417

2 references