The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif (Q24564692)

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S A Richards

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N R Orem

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I G Macara

Proceedings of the National Academy of Sciences of the United States of America

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publication date

11 April 1995

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language of work or name

English

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published in

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volume

92

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issue

8

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page(s)

3328-32

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cites work

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The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis

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A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation

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