CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice (Q24337733)

positive regulation of stem cell proliferation

GOA release 2020-03-11

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GOA release 2020-03-11

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5

Polina Goichberg

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Kfir Lapid

Kfir Lapid

2

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Vyacheslav Kalchenko

Vyacheslav Kalchenko

3

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Tsvee Lapidot

9

Tsvee Lapidot

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Orit Kollet

8

Orit Kollet

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Alexander Kalinkovich

6

Alexander Kalinkovich

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Shoham Shivtiel

1

Shoham Shivtiel

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author name string

Abraham Avigdor

4

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Arnon Nagler

BMEC-1: a human bone marrow microvascular endothelial cell line with primary cell characteristics

7

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language of work or name

English

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publication date

December 2011

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published in

Experimental Hematology

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volume

39

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page(s)

1161-1170.e1

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issue

12

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cites work

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Clinical use of umbilical cord blood hematopoietic stem cells

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Stem cell trafficking in tissue development, growth, and disease

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Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45.

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In vivo homing and differentiation characteristics of mature (CD45-) and immature (CD45+) 5T multiple myeloma cells

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CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

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Potent reversible inhibitors of the protein tyrosine phosphatase CD45.

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Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma.

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Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

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Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?

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Hematopoietic stem cells: generation and self-renewal.

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Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin

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The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen

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CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.

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Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase, CD45.

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

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A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

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CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules

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Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

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CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

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CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn.

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Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

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How do stem cells find their way home?

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Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines.

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Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

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Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice

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Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity

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Adhesion signaling - crosstalk between integrins, Src and Rho.

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Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis

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The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis

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CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes.

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CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro

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