Identification of a physiological E2 module for the human anaphase-promoting complex (Q24328862)

Ubiquitin conjugating enzyme E2 S

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ubiquitin-protein transferase activity

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Vihar Dmel_CG10682

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Uncharacterized protein Dmel_CG8188

1 reference

Barbara G Mellone

3

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Michael Rape

object named as

Michael Rape

6

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Gary H. Karpen

5

object named as

Gary H Karpen

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author name string

Adam Williamson

1

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Katherine E Wickliffe

2

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Ling Song

Proceedings of the National Academy of Sciences of the United States of America

4

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publication date

27 October 2009

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language of work or name

English

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published in

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volume

106

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issue

43

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page(s)

18213-8

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cites work

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A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons

19 March 2017

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UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

19 March 2017

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Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

19 March 2017

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

19 March 2017

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Genes required for mitotic spindle assembly in Drosophila S2 cells

19 March 2017

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Mitotic regulation of the human anaphase-promoting complex by phosphorylation

19 March 2017

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APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting Complex

19 March 2017

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The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

19 March 2017

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CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

19 March 2017

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

19 March 2017

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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis

19 March 2017

1 reference

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Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference

19 March 2017

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Modification of proteins by ubiquitin and ubiquitin-like proteins

19 March 2017

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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

19 March 2017

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

19 March 2017

1 reference

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

19 March 2017

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Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

19 March 2017

1 reference

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The anaphase promoting complex/cyclosome: a machine designed to destroy

7 April 2017

1 reference

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UbcH10 is overexpressed in malignant breast carcinomas

7 April 2017

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Cdc20: a WD40 activator for a cell cycle degradation machine

27 September 2017

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E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

27 September 2017

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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

27 September 2017

1 reference

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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

27 September 2017

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D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p

27 September 2017

1 reference

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The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

30 May 2018

1 reference

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Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells

30 May 2018

1 reference

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Clinicopathological relevance of UbcH10 in breast cancer

29 November 2018

1 reference

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The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

Global changes to the ubiquitin system in Huntington's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

Sequential E2s drive polyubiquitin chain assembly on APC targets

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775311

Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5

29 November 2018

1 reference

12 December 2020

Regulated separation of sister centromeres depends on the spindle assembly checkpoint but not on the anaphase promoting complex/cyclosome

1 reference

12 December 2020

Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins

1 reference

12 December 2020

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0907887106

1 reference

ADS bibcode

2009PNAS..10618213W

0 references

1 reference

1 reference

PubMed publication ID

19822757

1 reference