Involvement of an Active-site Zn2+ Ligand in the Catalytic Mechanism of Human Glyoxalase I (Q24323845)

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5 January 2025

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GOA release 2020-03-11

zinc ion binding

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GOA release 2020-03-11

2

A. D. Cameron

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5 January 2025

author name string

M. Ridderström

1

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T. A. Jones

3

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5 January 2025

B. Mannervik

4

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http://www.jbc.org/content/273/34/21623.full.pdf

5 January 2025

publication date

21 August 1998

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language of work or name

English

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work available at URL

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https://api.elsevier.com/content/article/PII:S0021925818488291?httpAccept=text/xml

5 January 2025

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https://api.elsevier.com/content/article/PII:S0021925818488291?httpAccept=text/plain

5 January 2025

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https://api.crossref.org/works/10.1074/JBC.273.34.21623

https://syndication.highwire.org/content/doi/10.1074/jbc.273.34.21623

5 January 2025

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Journal of Biological Chemistry

5 January 2025

published in

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volume

273

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issue

34

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page(s)

21623-8

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cites work

The glyoxalase system in health and disease

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Glyoxalase I, a zinc metalloenzyme of mammals and yeast

21 January 2018

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Probing the active site of glyoxalase I from human erythrocytes by use of the strong reversible inhibitor S-p-bromobenzylglutathione and metal substitutions

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Crystal structure of human glyoxalase I_evidence for gene duplication and 3D domain swapping

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Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion.

21 January 2018

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Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties

21 January 2018

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Optimized heterologous expression of the human zinc enzyme glyoxalase I

21 January 2018

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The CCP4 suite: programs for protein crystallography

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AMoRe: an automated package for molecular replacement

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Refinement of macromolecular structures by the maximum-likelihood method

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Automated refinement of protein models

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Accurate bond and angle parameters for X-ray protein structure refinement

21 January 2018

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The primary structure of monomeric yeast glyoxalase I indicates a gene duplication resulting in two similar segments homologous with the subunit of dimeric human glyoxalase I.

21 January 2018

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Molecular characterization of glyoxalase-I from a higher plant; upregulation by stress.

21 January 2018

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Identification of the structural gene for glyoxalase I from Saccharomyces cerevisiae

21 January 2018

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The gene encoding glyoxalase I from Pseudomonas putida: cloning, overexpression, and sequence comparisons with human glyoxalase I.

21 January 2018

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Isolation and sequencing of a gene coding for glyoxalase I activity from Salmonella typhimurium and comparison with other glyoxalase I sequences

21 January 2018

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Mutagenesis of residue 157 in the active site of human glyoxalase I

21 January 2018

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A convenient quantitative synthesis of methylglyoxal for glyoxalase I assays

21 January 2018

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7 January 2021

Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significance

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7 January 2021

Electron paramagnetic resonance study of the active site of copper-substituted human glyoxalase I

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7 January 2021

Evidence for a (triosephosphate isomerase-like) "catalytic loop" near the active site of glyoxalase I

1 reference

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7 January 2021

Evaluation of model discrimination, parameter estimation and goodness of fit in nonlinear regression problems by test statistics distributions

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