Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes (Q24323167)

regulation of transcription, DNA-templated

GOA release 2020-03-11

1 reference

Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

C Luo

1

C

Luo

1 reference

23 October 2023

E Burgeon

2

E

Burgeon

1 reference

23 October 2023

J A Carew

3

J A

Carew

1 reference

23 October 2023

P G McCaffrey

4

P G

McCaffrey

1 reference

23 October 2023

T M Badalian

5

T M

Badalian

1 reference

23 October 2023

W S Lane

6

W S

Lane

1 reference

23 October 2023

P G Hogan

7

P G

Hogan

1 reference

23 October 2023

A Rao

8

A

Rao

1 reference

Molecular and Cellular Biology

23 October 2023

publication date

July 1996

0 references

language of work or name

English

0 references

published in

0 references

volume

16

0 references

issue

7

0 references

page(s)

3955-66

0 references

cites work

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Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding

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NF-AT components define a family of transcription factors targeted in T-cell activation

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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

19 March 2017

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Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

19 March 2017

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Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

19 March 2017

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Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)

19 March 2017

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Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system

19 March 2017

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Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells

19 March 2017

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NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

19 March 2017

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19 March 2017

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

7 April 2017

1 reference

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Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

7 April 2017

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Transcription of the interleukin 4 gene is regulated by multiple promoter elements

27 September 2017

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The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

27 September 2017

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Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

27 September 2017

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Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter

27 September 2017

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Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

27 September 2017

1 reference

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Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.

27 September 2017

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Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.

27 September 2017

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A common factor regulates both Th1- and Th2-specific cytokine gene expression

27 September 2017

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Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

27 September 2017

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The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT.

27 September 2017

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Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0.

27 September 2017

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27 September 2017

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27 September 2017

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NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

27 September 2017

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The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription

27 September 2017

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Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c

27 September 2017

1 reference

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Cyclosporin-A sensitive induction of NF-AT in murine B cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells

27 September 2017

1 reference

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A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

An Ion Pair in Class II Major Histocompatibility Complex Heterodimers Critical for Surface Expression and Peptide Presentation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

FcϵRI-mediated Induction of Nuclear Factor of Activated T-cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Identification of a putative regulator of early T cell activation genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

B-cell-specific enhancer activity of conserved upstream elements of the class II major histocompatibility complex DQB gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

An enhanced immune response in mice lacking the transcription factor NFAT1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

The Ca2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. Role of the autoinhibitory domain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Nuclear factor of activated T cells contains Fos and Jun.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231392

Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp

30 May 2018

1 reference

12 December 2020

Critical structural elements of the VP16 transcriptional activation domain

1 reference

12 December 2020

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation

1 reference

12 December 2020

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1 reference

12 December 2020

1 reference

12 December 2020

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells

1 reference

12 December 2020

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs

1 reference

12 December 2020

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.16.7.3955

1 reference

release_zg4xyack45bh3f6mi4lhcnkqme

Fatcat ID

0 references

1 reference

1 reference

1 reference