PTEN regulation by Akt-EGR1-ARF-PTEN axis (Q24321834)

Phosphatase and tensin homolog

1 reference

Early growth response 1

1 reference

negative regulation of cell population proliferation

1 reference

Early growth response 1

1 reference

Tumor suppressor ARF

1 reference

author name string

Jianxiu Yu

1

0 references

Sharon S Zhang

2

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Kan Saito

3

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Scott Williams

4

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Yutaka Arimura

5

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Yuliang Ma

6

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Yuehai Ke

7

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Veronique Baron

8

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Dan Mercola

9

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Gen-Sheng Feng

10

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Eileen Adamson

11

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Tomas Mustelin

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

12

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language of work or name

English

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publication date

7 January 2009

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published in

The EMBO Journal

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volume

28

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page(s)

21-33

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issue

1

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cites work

1 reference

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Divorcing ARF and p53: an unsettled case

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Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53

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Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation

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A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells

27 September 2017

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Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras

27 September 2017

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p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.

27 September 2017

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Transactivation of the EGR1 gene contributes to mutant p53 gain of function

27 September 2017

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P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.

27 September 2017

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The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

27 September 2017

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Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation

27 September 2017

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Human ARF protein interacts with topoisomerase I and stimulates its activity

27 September 2017

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p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

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The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1.

27 September 2017

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

27 September 2017

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27 September 2017

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Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

27 September 2017

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Genetic interactions between Pten and p53 in radiation-induced lymphoma development.

30 May 2018

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The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor.

21 January 2018

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MDM2-ARF complex regulates p53 sumoylation

29 November 2018

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

29 November 2018

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12 December 2020

Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation

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12 December 2020

Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2

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12 December 2020

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

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12 December 2020

Ubiquitination of, and sumoylation by, the Arf tumor suppressor

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12 December 2020

The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

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12 December 2020

Epigenetic silencing of the PTEN gene in melanoma

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12 December 2020