The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding (Q24321603)

8

0 references

Matthias Zebisch

5

0 references

author name string

Anja Hauburger

1

0 references

Sabrina von Einem

2

0 references

Gerburg K Schwaerzer

3

0 references

Anja Buttstedt

4

0 references

Michael Schräml

6

0 references

Peter Hortschansky

7

0 references

Elisabeth Schwarz

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding

9

0 references

language of work or name

English

0 references

publication date

November 2009

0 references

published in

FEBS Journal

0 references

volume

276

0 references

page(s)

6386-98

0 references

issue

21

0 references

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The cystine-knot growth-factor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Signal transduction of bone morphogenetic protein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Dissecting the diverse actions of pro- and mature neurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Jekyll-Hyde neurotrophins: the story of proNGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Characterization and identification of the inhibitory domain of GDF-8 propeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Regulation of myostatin activity and muscle growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Crystal structure of BMP-9 and functional interactions with pro-region and receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Brachydactyly type A2 associated with a defect in proGDF5 processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Cooperativity of binding epitopes and receptor chains in the BMP/TGFbeta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Crystal structure of the BMP-2-BRIA ectodomain complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Heparin inhibits BMP-2 osteogenic bioactivity by binding to both BMP-2 and BMP receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Development of an enzyme-linked immunoreceptor assay (ELIRA) for quantification of the biological activity of recombinant human bone morphogenetic protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

7 January 2021

The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

7 January 2021

Clinical evaluation of recombinant human bone morphogenetic protein-2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

7 January 2021

Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

7 January 2021

Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07361.X

7 January 2021