Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation (Q24315019)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0039658

DEAD-box helicase 3 X-linked

1 reference

positive regulation of transcription by RNA polymerase II

GOA release 2020-03-11

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DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication

GOA release 2020-03-11

Andrew G Bowie

3

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author name string

Martina Schröder

series ordinal

1

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Marcin Baran

series ordinal

2

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publication date

6 August 2008

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language of work or name

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27

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issue

15

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page(s)

2147-57

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cites work

1 reference

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Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein

19 March 2017

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

19 March 2017

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DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor

19 March 2017

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

19 March 2017

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

19 March 2017

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Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10

19 March 2017

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Hepatitis C virus core protein binds to a DEAD box RNA helicase

19 March 2017

1 reference

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Hepatitis C virus core protein interacts with a human DEAD box protein DDX3

19 March 2017

1 reference

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Hepatitis C virus core protein interacts with cellular putative RNA helicase

19 March 2017

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IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

19 March 2017

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Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP

19 March 2017

1 reference

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Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity

19 March 2017

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5'-Triphosphate RNA is the ligand for RIG-I

19 March 2017

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

19 March 2017

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

19 March 2017

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

19 March 2017

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

19 March 2017

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Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

19 March 2017

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Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

19 March 2017

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

19 March 2017

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Cell type-specific involvement of RIG-I in antiviral response

19 March 2017

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Cytosolic DNA recognition for triggering innate immune responses

7 April 2017

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Oncogenic role of DDX3 in breast cancer biogenesis.

27 September 2017

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The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays

27 September 2017

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Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta

27 September 2017

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DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

27 September 2017

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How Toll-like receptors signal: what we know and what we don't know

27 September 2017

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Viral and cellular RNA helicases as antiviral targets

27 September 2017

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TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

27 September 2017

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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

27 September 2017

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

27 September 2017

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The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

27 September 2017

1 reference

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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

27 September 2017

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Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

27 September 2017

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

30 May 2018

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Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses

29 November 2018

1 reference

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29 November 2018

Identifiers

DOI

10.1038/EMBOJ.2008.143

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1 reference

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PubMed publication ID

18636090

1 reference