Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2 (Q24314295)

negative regulation of lipid transport across blood-brain barrier

Gene Ontology ID

GO:1990379

1 reference

positive regulation of lipid transport across blood-brain barrier

Gene Ontology ID

GO:1903001

2 references

Gene Ontology ID

GO:1903002

regulation of lipid transport across blood-brain barrier

GOA release 2020-03-11

1 reference

1 reference

GOA release 2020-03-11

author

Cyntia Tremblay

3

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Frédéric Calon

6

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Mélanie Plourde

7

object named as

Mélanie Plourde

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author name string

Milène Vandal

1

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Wael Alata

2

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Christine Rioux-Perreault

4

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Norman Salem

Journal of Neurochemistry

5

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language of work or name

English

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publication date

May 2014

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published in

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volume

129

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page(s)

516-26

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issue

3

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cites work

The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype

1 reference

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex

21 January 2018

1 reference

DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice

21 January 2018

1 reference

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

21 January 2018

1 reference

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype

21 January 2018

1 reference

Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.

21 January 2018

1 reference

APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old.

21 January 2018

1 reference

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

21 January 2018

1 reference

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

21 January 2018

1 reference

Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats

21 January 2018

1 reference

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

21 January 2018

1 reference

Omega-3 polyunsaturated fatty acids in Alzheimer's disease: key questions and partial answers.

21 January 2018

1 reference

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

21 January 2018

1 reference

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele.

21 January 2018

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

21 January 2018

1 reference

Fish, docosahexaenoic acid and Alzheimer's disease

21 January 2018

1 reference

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

21 January 2018

1 reference

Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk

21 January 2018

1 reference

The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system

21 January 2018

1 reference

Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport

21 January 2018

1 reference

Diet and risk of dementia: Does fat matter?: The Rotterdam Study

21 January 2018

1 reference

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

1 reference

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice

21 January 2018

1 reference

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

21 January 2018

1 reference

A model for fatty acid transport into the brain.

21 January 2018

1 reference

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

21 January 2018

1 reference

Apolipoprotein E: from lipid transport to neurobiology

21 January 2018

1 reference

Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele

21 January 2018

1 reference

Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils

21 January 2018

1 reference

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

21 January 2018

1 reference

Fatty acids, lipid metabolism and Alzheimer pathology.

21 January 2018

1 reference

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

21 January 2018

1 reference

Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.

21 January 2018

1 reference

Apolipoprotein E and cognitive change in an elderly population.

21 January 2018

1 reference

Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults

21 January 2018

1 reference

Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

21 January 2018

1 reference

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

21 January 2018

1 reference

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

21 January 2018

1 reference

Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain.

21 January 2018

1 reference

Polyunsaturated fatty acids, neuroinflammation and well being.

21 January 2018

1 reference

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

21 January 2018

1 reference

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

21 January 2018

1 reference

Apolipoprotein E: far more than a lipid transport protein

21 January 2018

1 reference

Effects of ω-3 fatty acids on cognitive performance: a meta-analysis

21 January 2018

1 reference

Fatty acid transport into the brain: of fatty acid fables and lipid tails

21 January 2018

1 reference

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease

21 January 2018

1 reference

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.

21 January 2018

1 reference

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements

21 January 2018

1 reference

Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly

21 January 2018

1 reference

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.

21 January 2018

1 reference

Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly

21 January 2018

1 reference

Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers.

21 January 2018

1 reference

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

21 January 2018

1 reference

Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission

21 January 2018

1 reference

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

21 January 2018

1 reference

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

21 January 2018

1 reference

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

21 January 2018

1 reference

ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression

21 January 2018

1 reference

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon

21 January 2018

1 reference

Apolipoprotein E and cognitive performance: a meta-analysis.

21 January 2018

1 reference

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

21 January 2018

1 reference

Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes.

21 January 2018

1 reference

Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography

21 January 2018

1 reference

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.

21 January 2018

1 reference

Effect of plasma lipids, hypertension and APOE genotype on cognitive decline

21 January 2018

1 reference

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

21 January 2018

1 reference

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

21 January 2018

1 reference

APOE genotype alters glial activation and loss of synaptic markers in mice

21 January 2018

1 reference

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

21 January 2018

1 reference

7 January 2021

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

7 January 2021

n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood

1 reference

7 January 2021

(n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats.

1 reference

7 January 2021

Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoate

1 reference

7 January 2021

Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1 reference

7 January 2021

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

1 reference

7 January 2021

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol.

1 reference

7 January 2021

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease

1 reference

7 January 2021