Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation (Q24313100)

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D Cefai

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H Schneider

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M Raab

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N Nabavi

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C E Rudd

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

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language of work or name

English

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publication date

October 1995

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published in

Immunity

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volume

3

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page(s)

417-26

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issue

4

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cites work

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Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin

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T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

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p21ras mediates control of IL-2 gene promoter function in T cell activation.

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

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AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

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Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

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JNK is involved in signal integration during costimulation of T lymphocytes.

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

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Mechanisms of CD28 signalling

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Molecules involved in T-cell costimulation

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CTLA-4 can function as a negative regulator of T cell activation

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Absence of B7-dependent responses in CD28-deficient mice

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B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

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Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

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Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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B70 antigen is a second ligand for CTLA-4 and CD28.

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

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The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells

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Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

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Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

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Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

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The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

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CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

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Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

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CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

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7 January 2021

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

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Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule

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The Son of sevenless Gene Product: a Putative Activator of Ras

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Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

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Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

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Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

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Differential T cell costimulatory requirements in CD28-deficient mice

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Identification of an alternative CTLA-4 ligand costimulatory for T cell activation

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Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice

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Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

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7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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7 January 2021

The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

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7 January 2021

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

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7 January 2021

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

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7 January 2021

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

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7 January 2021

The role of the CD28 receptor during T cell responses to antigen

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1644199

1644199

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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