DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway (Q24312506)

Thioredoxin

1 reference

Parkinsonism associated deglycase

1 reference

positive regulation of transcription regulatory region DNA binding

1 reference

Parkinson disease (autosomal recessive, early onset) 7

1 reference

Joo-Young Im

1

Joo-Young

Im

1 reference

20 October 2023

Kang-Woo Lee

2

Kang-Woo

Lee

1 reference

20 October 2023

Jong-Min Woo

3

Jong-Min

Woo

1 reference

20 October 2023

Eunsung Junn

4

Eunsung

Junn

1 reference

20 October 2023

M Maral Mouradian

5

M Maral

describes a project that uses

Mouradian

1 reference

20 October 2023

language of work or name

English

0 references

publication date

1 July 2012

0 references

published in

Human Molecular Genetics

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volume

21

0 references

page(s)

3013-24

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issue

13

0 references

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3373246/fullTextXML

inferred from PubMed Central ID database lookup

cites work

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

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DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor

19 March 2017

1 reference

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

19 March 2017

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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

19 March 2017

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

19 March 2017

1 reference

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DJ-1 has a role in antioxidative stress to prevent cell death

19 March 2017

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The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

19 March 2017

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

19 March 2017

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DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

19 March 2017

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

19 March 2017

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

19 March 2017

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

19 March 2017

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Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1

19 March 2017

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Oxidative stress in neurodegeneration: cause or consequence?

19 March 2017

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DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex

19 March 2017

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DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity

19 March 2017

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

19 March 2017

1 reference

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

19 March 2017

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Multiple coregulatory control of tyrosine hydroxylase gene transcription

7 April 2017

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CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation

27 September 2017

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DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.

27 September 2017

1 reference

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Keap1-Nrf2 activation in the presence and absence of DJ-1.

27 September 2017

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Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.

27 September 2017

1 reference

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DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

27 September 2017

1 reference

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Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.

27 September 2017

1 reference

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Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

27 September 2017

1 reference

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Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin

27 September 2017

1 reference

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Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

27 September 2017

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Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation

27 September 2017

1 reference

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Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

27 September 2017

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Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1.

27 September 2017

1 reference

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

27 September 2017

1 reference

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

27 September 2017

1 reference

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Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation

27 September 2017

1 reference

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Nuclear import and export signals in control of Nrf2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

DJ-1, a novel regulator of the tumor suppressor PTEN.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Oxidatively modified proteins in aging and disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Redox regulation of cellular activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Elevation of antioxidant potency in the brain of mice by low-dose gamma-ray irradiation and its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage.

30 May 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS131

Does thioredoxin-1 prevent mitochondria- and endoplasmic reticulum-mediated neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS131

Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS131

Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS131

Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS131

A rapid and efficient PCR-based mutagenesis method applicable to cell physiology study.

21 January 2018

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21 January 2018

1 reference

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Antioxidant capacity in postmortem brain tissues of Parkinson's and Alzheimer's diseases.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373246

Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22492997

12 December 2020

inferred from PubMed ID database lookup

Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22492997

12 December 2020

inferred from PubMed ID database lookup

Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22492997

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/HMG/DDS131

1 reference

release_2geq5tssmrg7bpwizo5fm5b4ci

1292206

Fatcat ID

0 references

1292206

1 reference

1 reference

1 reference