Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation (Q24305419)

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English	Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation	scientific article

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scholarly article

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Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation (English)

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Parkinson's disease

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inferred from title

Leucine rich repeat kinase 2

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

author name string

Etsuro Ohta

1

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Fumitaka Kawakami

2

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Makoto Kubo

3

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Fumiya Obata

4

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language of work or name

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publication date

11 January 2013

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Biochemical and Biophysical Research Communications

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430

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560-6

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2

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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Mendelian forms of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

The RIP kinases: crucial integrators of cellular stress

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinase activity of mutant LRRK2 mediates neuronal toxicity

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of LRRK2: from kinase to substrate

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

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https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBRC.2012.11.113

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.BBRC.2012.11.113

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release_vb3wgrss7rgh5ltahr32v23zzq

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ResearchGate publication ID

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