Rocks: multifunctional kinases in cell behaviour (Q24303641)

Rho-dependent protein serine/threonine kinase activity

Europe PubMed Central

title

Rocks: multifunctional kinases in cell behaviour (English)

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main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0072518

Rho associated coiled-coil containing protein kinase 1

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Rho associated coiled-coil containing protein kinase 2

GOA release 2020-03-11

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regulation of cell motility

GOA release 2020-03-11

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Nature Reviews Molecular Cell Biology

GOA release 2020-03-11

2

Anne J Ridley

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author name string

Kirsi Riento

series ordinal

1

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language of work or name

English

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publication date

June 2003

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published in

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volume

4

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page(s)

446-56

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issue

6

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cites work

The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3.

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

31 March 2020

1 reference

Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

31 March 2020

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

31 March 2020

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A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

31 March 2020

1 reference

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

31 March 2020

1 reference

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

31 March 2020

1 reference

Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7

31 March 2020

1 reference

Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase

31 March 2020

1 reference

RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network

31 March 2020

1 reference

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

31 March 2020

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Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments

31 March 2020

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Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies

31 March 2020

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Rho-kinase--mediated contraction of isolated stress fibers

31 March 2020

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The Rho-associated protein kinase p160ROCK is required for centrosome positioning

31 March 2020

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Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

31 March 2020

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

31 March 2020

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Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

31 March 2020

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Rho-associated kinase of chicken gizzard smooth muscle

31 March 2020

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Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells

31 March 2020

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Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha

31 March 2020

1 reference

Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition

31 March 2020

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p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

31 March 2020

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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

31 March 2020

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Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

31 March 2020

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The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

31 March 2020

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31 March 2020

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The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.

31 March 2020

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Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

31 March 2020

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Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

31 March 2020

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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

31 March 2020

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Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

31 March 2020

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A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea

31 March 2020

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Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.

31 March 2020

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Myosin phosphatase: subunits and interactions

31 March 2020

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

31 March 2020

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Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

31 March 2020

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Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

31 March 2020

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

31 March 2020

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Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

31 March 2020

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Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site

31 March 2020

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Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

31 March 2020

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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

31 March 2020

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Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2

31 March 2020

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

31 March 2020

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Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility

31 March 2020

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Adducin: Ca++-dependent association with sites of cell-cell contact

31 March 2020

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Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

31 March 2020

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

31 March 2020

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Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

31 March 2020

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Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase

31 March 2020

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RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

31 March 2020

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RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate

31 March 2020

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Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

31 March 2020

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Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.

31 March 2020

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Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading

31 March 2020

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Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation

31 March 2020

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

31 March 2020

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Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis

31 March 2020

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Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.

31 March 2020

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Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase

31 March 2020

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Elongation factor-1 alpha is a novel substrate of rho-associated kinase

31 March 2020

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Rho-associated kinase phosphorylates MARCKS in human neuronal cells

31 March 2020

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Identification of calponin as a novel substrate of Rho-kinase

31 March 2020

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Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse

31 March 2020

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Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

31 March 2020

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CRMP-2 induces axons in cultured hippocampal neurons

31 March 2020

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p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology

31 March 2020

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Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells

31 March 2020

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CD44v10 interaction with Rho-kinase (ROK) activates inositol 1,4,5-triphosphate (IP3) receptor-mediated Ca2+ signaling during hyaluronan (HA)-induced endothelial cell migration

31 March 2020

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Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.

31 March 2020

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Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

31 March 2020

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Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

31 March 2020

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mDia mediates Rho-regulated formation and orientation of stable microtubules

31 March 2020

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p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

31 March 2020

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Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia.

31 March 2020

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ROCK and Dia have opposing effects on adherens junctions downstream of Rho

31 March 2020

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Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium

31 March 2020

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RhoA is required for monocyte tail retraction during transendothelial migration

31 March 2020

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Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

31 March 2020

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Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

31 March 2020

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ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

31 March 2020

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RhoA and ROCK promote migration by limiting membrane protrusions

31 March 2020

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ADF/Cofilin Controls Cell Polarity during Fibroblast Migration

31 March 2020

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A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes

31 March 2020

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Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.

31 March 2020

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Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements.

31 March 2020

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

31 March 2020

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

31 March 2020

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Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.

31 March 2020

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

31 March 2020

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Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

31 March 2020

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

31 March 2020

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Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

31 March 2020

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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

31 March 2020

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Transformation mediated by RhoA requires activity of ROCK kinases

31 March 2020

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Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases

31 March 2020

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Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis

31 March 2020

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Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation

31 March 2020

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Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells

31 March 2020

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NGF induces neurite outgrowth via a decrease in phosphorylation of myosin light chain in PC12 cells

31 March 2020

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p160 RhoA-binding kinase ROKalpha induces neurite retraction

31 March 2020

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Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

31 March 2020

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A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons

31 March 2020

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Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

31 March 2020

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Nerve growth factor and semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility.

31 March 2020

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Rho signaling pathway targeted to promote spinal cord repair.

31 March 2020

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Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.

31 March 2020

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Inhibition of neurite extension by overexpression of individual domains of LIM kinase 1.

31 March 2020

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Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

31 March 2020

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RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway

31 March 2020

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Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity

31 March 2020

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Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase

31 March 2020

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CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

31 March 2020

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A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.

31 March 2020

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Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.

31 March 2020

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Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments

31 March 2020

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Role of citron kinase as a target of the small GTPase Rho in cytokinesis.

31 March 2020

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Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development

31 March 2020

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A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling.

31 March 2020

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Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

31 March 2020

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p21-activated kinases: three more join the Pak.

31 March 2020

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Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity

31 March 2020

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Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

31 March 2020

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Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase

31 March 2020

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

31 March 2020

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Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

31 March 2020

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Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

31 March 2020

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Inhibition of myosin light chain kinase by p21-activated kinase

31 March 2020

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Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

31 March 2020

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