The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins (Q24302423)

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3 November 2019

title

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins (English)

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3 November 2019

2

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3 November 2019

author name string

Jun He

1

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3 November 2019

Ariel R Krawitz

3

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3 November 2019

G Steven Martin

4

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3 November 2019

Kunxin Luo

5

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3 November 2019

language of work or name

English

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publication date

22 May 2003

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Journal of Biological Chemistry

3 November 2019

published in

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3 November 2019

volume

278

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3 November 2019

page(s)

30540-30547

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3 November 2019

issue

33

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Isolation of human cDNA clones of ski and the ski-related gene, sno

3 November 2019

cites work

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A domain necessary for the transforming activity of SnoN is required for specific DNA binding, transcriptional repression and interaction with TAF(II)110.

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c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

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The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

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Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1074/JBC.M304016200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12764135%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference