An acetylation switch in p53 mediates holo-TFIID recruitment (Q24300158)

TATA-box binding protein associated factor 1

GOA release 2020-03-11

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GOA release 2020-03-11

tumor protein p53

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GOA release 2020-03-11

author name string

Andrew G Li

1

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Landon G Piluso

2

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Xin Cai

3

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Brian J Gadd

4

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Andreas G Ladurner

5

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Xuan Liu

Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators

6

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language of work or name

English

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publication date

9 November 2007

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published in

Molecular Cell

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volume

28

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page(s)

408-21

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issue

3

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cites work

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

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Purification of acetyl-p53 using p300 co-infection and the baculovirus expression system.

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74

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The TAF(II)250 subunit of TFIID has histone acetyltransferase activity

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p53: good cop/bad cop.

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Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

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TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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Ordered recruitment: gene-specific mechanism of transcription activation

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Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

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Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

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TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

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