Molecular biology and function of CD4 and CD8 (Q24299317)

Cell-mediated cytotoxicity against HLA-D-region products expressed in monocytes and B lymphocytes. IV. Characterization of effector cells using monoclonal antibodies against human T-cell subsets

Europe PubMed Central

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Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma

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Perturbation of the T4 molecule transmits a negative signal to T cells

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7 January 2021

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4.

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7 January 2021

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus

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7 January 2021

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens

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7 January 2021

Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of CTL-target cell binding

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7 January 2021

Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.

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7 January 2021

Molecular interactions in T-cell-mediated cytotoxicity

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7 January 2021

Physical association between the CD8 and HLA class I molecules on the surface of activated human T lymphocytes

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7 January 2021

The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans

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A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.

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7 January 2021

Lymphocytes as Models for the Study of Mammalian Cellular Differentiation

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7 January 2021

Involvement of the CD4 molecule in a post-activation event on T cell proliferation

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7 January 2021

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5

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7 January 2021

Human immunodeficiency virus can productively infect cultured human glial cells

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7 January 2021

Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains

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7 January 2021

Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds

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7 January 2021

The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like

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7 January 2021

Species heterogeneity in macrophage expression of the CD4 antigen

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7 January 2021

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

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7 January 2021

A soluble form of CD4 (T4) protein inhibits AIDS virus infection

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7 January 2021

Transfer of specificity by murine alpha and beta T-cell receptor genes

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7 January 2021

Transfection of the CD8 gene enhances T-cell recognition

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7 January 2021

Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells

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7 January 2021

Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV).

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7 January 2021

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

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7 January 2021

Interaction between CD4 and class II MHC molecules mediates cell adhesion

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7 January 2021

Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4

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7 January 2021

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen

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7 January 2021

Selective stimulation of human T lymphocyte subsets by heteroconjugates of antibodies to the T cell receptor and to subset-specific differentiation antigens

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7 January 2021

Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man

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7 January 2021

Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen

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7 January 2021

Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2+ L3T4+ T-cell clones

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7 January 2021

Human immunodeficiency virus induces phosphorylation of its cell surface receptor

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7 January 2021

HIV infection is blocked in vitro by recombinant soluble CD4.

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7 January 2021

Do CD4 or CD8 molecules provide a regulatory signal in T-cell activation?

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7 January 2021

Triggering of the lethal hit in human cytotoxic T lymphocytes: a functional role for a 103-kDa T cell-specific activation antigen

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7 January 2021

Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency

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7 January 2021

Spontaneous release of the Leu-2 (T8) molecule from human T cells

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7 January 2021

Immunochemical analysis of the released Leu-2 (T8) molecule

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7 January 2021

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

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7 January 2021

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

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7 January 2021

Stable expression of Lyt-2 homodimers on L3T4+ T cell clones

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7 January 2021

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

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7 January 2021

Structure of the mouse gene encoding CD4 and an unusual transcript in brain

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7 January 2021

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency

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7 January 2021

Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen

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7 January 2021

The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma

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7 January 2021

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

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7 January 2021

Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome

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7 January 2021

Effects of anti-Lyt antibodies on T-cell functions

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7 January 2021

Blocking effect of lyt-2 antibodies on T cell functions

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7 January 2021

Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV

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7 January 2021

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells

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7 January 2021

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

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7 January 2021

The gene encoding the T-cell surface protein T4 is located on human chromosome 12

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7 January 2021

Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse

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7 January 2021

Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein

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7 January 2021

CD4+ T cells: specificity and function.

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7 January 2021

Mouse Lyt-2 antigen: evidence for two heterodimers with a common subunit

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7 January 2021

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages

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7 January 2021

A human homolog of the mouse CD8 molecule, Lyt-3: genomic sequence and expression

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7 January 2021

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7 January 2021

Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction

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7 January 2021

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

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7 January 2021

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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7 January 2021

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

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7 January 2021

Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1

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7 January 2021

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

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7 January 2021

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

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7 January 2021

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells

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7 January 2021

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4.

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7 January 2021

Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies

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7 January 2021

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

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7 January 2021

The Lyt-2, Lyt-3 macromolecules: structural and functional studies

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7 January 2021

Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity

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7 January 2021

Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor

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7 January 2021

Murine T cell receptor beta chain is encoded on chromosome 6

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7 January 2021

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

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7 January 2021

The structure of the CD4 and CD8 genes

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7 January 2021

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

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7 January 2021

The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes

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7 January 2021

Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack

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7 January 2021

Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

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7 January 2021

Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

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7 January 2021

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

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7 January 2021

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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7 January 2021

Structure and expression of the human and mouse T4 genes

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7 January 2021

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product

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7 January 2021

An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction

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7 January 2021

Cell surface antigen expression on thymocytes: development and phenotypic differentiation of intrathymic subsets

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7 January 2021

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions

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7 January 2021

Surface structures involved in target recognition by human cytotoxic T lymphocytes

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7 January 2021

Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function

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7 January 2021

Surface markers of cloned human T cells with various cytolytic activities

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7 January 2021

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions

1 reference

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7 January 2021

Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Human T cell antigens involved in cytotoxicity against allogeneic or autologous chemically modified targets. Association of the Leu 2a/T8 antigen with effector-target cell binding and of the T3/Leu 4 antigen with triggering

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Accessory molecules and T cell activation. II. Antibody binding to L3T4a inhibits Ia-independent mouse T cell proliferation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Expression and function of CD8 in a murine T cell hybridoma

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The differentiation and function of human T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Separation of functional subsets of human T cells by a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

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7 January 2021

Insulin-specific T cell hybridomas derived from (H-2b x H-2k)F1 mice preferably employ F1-unique restriction elements for antigen recognition

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Lyt-2 glycoprotein is synthesized as a single molecular species

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The CD4 antigen: physiological ligand and HIV receptor

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone

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7 January 2021

T cell development in the adult murine thymus: changes in the expression of the surface antigens Ly2, L3T4 and B2A2 during development from early precursor cells to emigrants

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7 January 2021

Mapping of the Ly-4 (L3T4) T-cell differentiation antigen on mouse chromosome 6 by the use of RFLPs in an interspecific cross

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain

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7 January 2021

HTLV-III infection in brains of children and adults with AIDS encephalopathy

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7 January 2021

Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Expression and function of CD4 in a murine T-cell hybridoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

CD4+ murine T cells develop from CD8+ precursors in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Comparison of Target Antigens of Monoclonal Reagents OKT5, OKT8, and Leu2A, which Inhibit Effector Function of Human Cytotoxic T Lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Association between the human thymic differentiation antigens T6 and T8.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

CD8B, the human equivalent of the mouse Ly-3 gene is localized on chromosome 2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: mechanism for persistence in AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

T Cell Subsets and the Recognition of MHC Class

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Soluble CD4 molecules neutralize human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Ly antigens associated with T cell recognition and effector function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Comparison of thymic and peripheral T cell Ly-2/3 antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

A small polypeptide different from beta2-microglobin associated with a human cell surface antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021

Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960644-6

7 January 2021