Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm (Q24297348)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

0 references

RUNX family transcription factor 3

1 reference

SRC proto-oncogene, non-receptor tyrosine kinase

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein phosphorylation

1 reference

GOA release 2020-03-11

1 reference

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Yun-Mi Goh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Senthilkumar Cinghu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Eileen Tan Hwee Hong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

You-Soub Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Jang-Hyun Kim

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Ju-Won Jang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Ying-Hui Li

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Xin-Zi Chi

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Kyeong-Sook Lee

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Heejun Wee

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Yoshiaki Ito

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Suk-Chul Bae

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

25 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

number of pages

8

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

10122-10129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

17 January 2020

cites work

1 reference

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

19 March 2017

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Src family kinases in tumor progression and metastasis

19 March 2017

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Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants

19 March 2017

1 reference

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

19 March 2017

1 reference

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

19 March 2017

1 reference

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CRM1 is an export receptor for leucine-rich nuclear export signals

19 March 2017

1 reference

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

19 March 2017

1 reference

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The RUNX genes: gain or loss of function in cancer

19 March 2017

1 reference

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Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk

19 March 2017

1 reference

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Causal relationship between the loss of RUNX3 expression and gastric cancer

19 March 2017

1 reference

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19 March 2017

The hunting of the Src

1 reference

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Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

19 March 2017

1 reference

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

19 March 2017

1 reference

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Cellular functions regulated by Src family kinases

7 April 2017

1 reference

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7 April 2017

A renaissance for SRC

1 reference

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Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes.

10 May 2017

1 reference

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Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization.

27 September 2017

1 reference

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Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal

27 September 2017

1 reference

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Src continues aging: current and future clinical directions.

27 September 2017

1 reference

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RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer

27 September 2017

1 reference

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Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2.

27 September 2017

1 reference

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Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography.

27 September 2017

1 reference

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Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.

27 September 2017

1 reference

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Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma

27 September 2017

1 reference

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Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines

27 September 2017

1 reference

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Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma

27 September 2017

1 reference

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Nucleocytoplasmic shuttling of signal transducers.

27 September 2017

1 reference

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Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma

27 September 2017

1 reference

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Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma

27 September 2017

1 reference

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TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity

27 September 2017

1 reference

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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

27 September 2017

1 reference

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Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia

27 September 2017

1 reference

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Core-binding factors in haematopoiesis and leukaemia

27 September 2017

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Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells

27 September 2017

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Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

27 September 2017

1 reference

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Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

27 September 2017

1 reference

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

30 May 2018

1 reference

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Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843174

Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia

21 January 2018

1 reference

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Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines

21 January 2018

1 reference

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Biological functions of melanoma-associated antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

The APC tumour suppressor has a nuclear export function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071381

RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2843174

Cancer: new-age tumour suppressors

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20100835

12 December 2020

inferred from PubMed ID database lookup

Breast cancer banishes p27 from nucleus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20100835

12 December 2020

inferred from PubMed ID database lookup

Parc-ing p53 in the cytoplasm

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20100835

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M109.071381

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100835%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

20100835

1 reference