SASH1 is a scaffold molecule in endothelial TLR4 signaling (Q24295323)

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

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Inhibitor of nuclear factor kappa B kinase subunit beta

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Nuclear factor kappa B subunit 1

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TNF receptor associated factor 6

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Mitogen-activated protein kinase 14

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Component of inhibitor of nuclear factor kappa B kinase complex

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C-X-C motif chemokine ligand 10

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Interleukin 6

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Mitogen-activated protein kinase 8

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Mitogen-activated protein kinase kinase kinase 7

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Interleukin 6

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Inhibitor of nuclear factor kappa-B kinase subunit alpha

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Linker for activation of T cells

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SAM and SH3 domain containing 1

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TNF receptor-associated factor 6

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Ubiquitin-conjugating enzyme E2N

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Ubiquitin-conjugating enzyme E2 variant 1

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Inhibitor of kappaB kinase beta

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Chemokine (C-X-C motif) ligand 10

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Mitogen-activated protein kinase 14

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Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

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Mitogen-activated protein kinase 8

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Mitogen-activated protein kinase kinase kinase 7

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Inhibitor of kappaB kinase gamma

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author name string

Shauna M Dauphinee

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Ashley Clayton

2

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Angela Hussainkhel

3

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Cindy Yang

4

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Yoo-Jin Park

5

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Megan E Fuller

6

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Josip Blonder

7

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Timothy D Veenstra

8

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Aly Karsan

The TRAF6 RING finger domain mediates physical interaction with Ubc13.

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language of work or name

English

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publication date

15 July 2013

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published in

Journal of Immunology

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volume

191

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page(s)

892-901

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issue

2

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cites work

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7 January 2021

TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

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The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

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Modulating leukocyte recruitment in inflammation

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The role of TRAF6 in signal transduction and the immune response

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Signaling to NF-kappaB by Toll-like receptors

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Scaffolds: interaction platforms for cellular signalling circuits.

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The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells.

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

Optimized method for computing (18)O/(16)O ratios of differentially stable-isotope labeled peptides in the context of postdigestion (18)O exchange/labeling

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Quantitative profiling of the detergent-resistant membrane proteome of iota-b toxin induced vero cells

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Proteomic analysis of lipid microdomains from lipopolysaccharide-activated human endothelial cells

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Proteomic analysis of plasma membrane from hypoxia-adapted malignant melanoma

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7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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Lipopolysaccharide signaling in endothelial cells

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The phosphoproteome of toll-like receptor-activated macrophages

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Distinct molecular mechanism for initiating TRAF6 signalling

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7 January 2021

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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7 January 2021

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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7 January 2021

Identification of membrane proteins from mammalian cell/tissue using methanol-facilitated solubilization and tryptic digestion coupled with 2D-LC-MS/MS

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7 January 2021

Scaffold proteins and immune-cell signalling

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7 January 2021

Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer

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Tumor necrosis factor receptor-associated factors (TRAFs)

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7 January 2021

SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer

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7 January 2021

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

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7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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7 January 2021

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

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7 January 2021

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

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7 January 2021

Approaches to define antigen receptor-induced serine kinase signal transduction pathways

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7 January 2021

TAK1-dependent signaling requires functional interaction with TAB2/TAB3

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7 January 2021

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

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7 January 2021

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

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7 January 2021

The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades

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7 January 2021

The roles of TLRs, RLRs and NLRs in pathogen recognition

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7 January 2021

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

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7 January 2021

Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1

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7 January 2021

Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands

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7 January 2021

FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction

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7 January 2021

Impaired immune responses and prolonged allograft survival in Sly1 mutant mice

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7 January 2021

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

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7 January 2021

Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-κB and c-Jun N-terminal kinase

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7 January 2021

Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS

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7 January 2021