The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex (Q24293680)

GOA release 2020-03-11

CD8 receptor binding

1 reference

GOA release 2020-03-11

author name string

E K Barber

1

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J D Dasgupta

2

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S F Schlossman

3

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J M Trevillyan

4

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C E Rudd

Proceedings of the National Academy of Sciences of the United States of America

5

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publication date

May 1989

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language of work or name

English

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published in

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volume

86

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issue

9

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page(s)

3277-81

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cites work

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The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

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The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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Protein-tyrosine kinases

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The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.

7 April 2017

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T Cell Subsets and the Recognition of MHC Class

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Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes

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Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

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Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation

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Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases

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HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells

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Perturbation of the T4 molecule transmits a negative signal to T cells

27 September 2017

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Discordance between surface and cytoplasmic expression of the Leu-4 (T3) antigen in thymocytes and in blast cells from childhood T lymphoblastic malignancies

27 September 2017

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Tyrosine protein kinase activity of rat spleen and other tissues.

27 September 2017

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The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product

30 May 2018

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Polyoma virus transforming protein associates with the product of the c-src cellular gene

30 May 2018

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Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity

30 May 2018

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Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.

30 May 2018

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Molecular cloning of the zeta chain of the T cell antigen receptor

30 May 2018

1 reference

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Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

30 May 2018

1 reference

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HLA-D region antigen-associated invariant polypeptides as revealed by two-dimensional gel analysis. Glycosylation and structural inter-relationships

30 May 2018

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Evidence for specific association between class I major histocompatibility antigens and the CD8 molecules of human suppressor/cytotoxic cells

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

Evidence against a dimeric structure for membrane-bound HLA antigens

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=287114

A one-step purification of membrane proteins using a high efficiency immunomatrix

29 November 2018

1 reference

12 December 2020

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins

1 reference

12 December 2020

Covalent association between human thymus leukemia-like antigens and CD8(Tp32) molecules

1 reference

12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1 reference

12 December 2020

Function of the CD4 and CD8 molecules on human cytotoxic T lymphocytes: regulation of T cell triggering

1 reference

12 December 2020

Participation of L3T4 in T cell activation in the absence of class II major histocompatibility complex antigens. Inhibition by anti-L3T4 antibodies is a function both of epitope density and mode of presentation of anti-receptor antibody

1 reference

12 December 2020

Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4

1 reference

12 December 2020

Association and dissociation of the murine T cell receptor associated protein (TRAP). Early events in the biosynthesis of a multisubunit receptor

1 reference

12 December 2020

Tyrosine phosphorylation of the human T cell antigen receptor zeta-chain: activation via CD3 but not CD2

1 reference

12 December 2020

Identification of the human T-lymphocyte protein-tyrosine kinase by peptide-specific antibodies

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.86.9.3277

1 reference

ADS bibcode

1989PNAS...86.3277B

0 references

1 reference

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PubMed publication ID

2470098

1 reference