An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor (Q24293598)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

John Kuriyan

5

0 references

author name string

Xuewu Zhang

1

0 references

Jodi Gureasko

2

0 references

Kui Shen

3

0 references

Philip A Cole

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

4

0 references

publication date

16 June 2006

0 references

language of work or name

0 references

0 references

125

0 references

issue

6

0 references

page(s)

1137-49

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A Putative Mechanism for Downregulation of the Catalytic Activity of the EGF Receptor via Direct Contact between Its Kinase and C-Terminal Domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

The conformational plasticity of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Template-Directed Assembly of Receptor Signaling Complexes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Untangling the ErbB signalling network

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Crystal structure of cyclin-dependent kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Mechanism-based design of a protein kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor c-terminal tail

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Structure of the extracellular region of HER3 reveals an interdomain tether

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Activation of Neu (ErbB-2) Mediated by Disulfide Bond-Induced Dimerization Reveals a Receptor Tyrosine Kinase Dimer Interface

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021

A Src-like inactive conformation in the abl tyrosine kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2006.05.013

7 January 2021