SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation (Q24293305)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

Hypoxia inducible factor 1 subunit alpha

12 March 2020

main subject

hypoxia

0 references

1 reference

Sirtuin 2

1 reference

positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

1 reference

Sirtuin 2

1 reference

author

Jun Young Heo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Jeong Su Han

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Chan Kim

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Minho Shong

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

K-S Seo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

J-H Park

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

K Jing

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

K-N Min

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

G Y Koh

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

K Lim

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

G-Y Kang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

J Uee Lee

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Y-H Yim

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

T-H Kwak

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

G R Kweon

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

English

0 references

publication date

31 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

1354-1362

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

cites work

Biology of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Inhibiting hypoxia-inducible factor 1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

HIF-1: upstream and downstream of cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Hypoxia, HIF1 and glucose metabolism in the solid tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Hypoxia-inducible factors and the response to hypoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

The many faces of insulin-like peptide signalling in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Hydroxylation of HIF-1: oxygen sensing at the molecular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

HIF1α protein stability is increased by acetylation at lysine 709.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

RTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Rapid degradation of hypoxia-inducible factor-1alpha by KRH102053, a new activator of prolyl hydroxylase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Redox sensor CtBP mediates hypoxia-induced tumor cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Sirtuins as regulators of metabolism and healthspan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.76

Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24681946

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2014.76

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24681946%20AND%20SRC:MED&resulttype=core&format=json