Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase (Q22253438)

intracellular signal transduction

GOA release 2020-03-11

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GOA release 2020-03-11

Y Wu

1

Y

Wu

1 reference

28 March 2023

D Dowbenko

2

D

Dowbenko

1 reference

28 March 2023

S Spencer

3

S

Spencer

1 reference

28 March 2023

R Laura

4

R

Laura

1 reference

28 March 2023

J Lee

5

J

Lee

1 reference

28 March 2023

Q Gu

6

Q

Gu

1 reference

28 March 2023

L A Lasky

7

L A

Lasky

1 reference

Journal of Biological Chemistry

28 March 2023

publication date

14 July 2000

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language of work or name

English

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published in

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volume

275

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issue

28

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page(s)

21477-85

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cites work

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

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Pten is essential for embryonic development and tumour suppression

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Mechanisms and consequences of activation of protein kinase B/Akt

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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Protein-protein interactions: PDZ domain networks

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PDZ domains: targeting signalling molecules to sub-membranous sites

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PDZ Proteins Organize Synaptic Signaling Pathways

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MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains

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Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins

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A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins

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Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

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Crystal structure of a PDZ domain

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

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Cloning and Characterization of BAI-Associated Protein 1: A PDZ Domain-Containing Protein That Interacts with BAI1

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Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions

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Ion channel targeting in neurons

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Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large

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PTEN and inherited hamartoma-cancer syndromes

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PTEN: Sometimes Taking It Off Can Be Better than Putting It On

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

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Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis

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The LIN-2/LIN-7/LIN-10 Complex Mediates Basolateral Membrane Localization of the C. elegans EGF Receptor LET-23 in Vulval Epithelial Cells

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A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

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SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density

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Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

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Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

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Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex

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PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

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Identifiers

DOI

10.1074/JBC.M909741199

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