Tumor necrosis factor (Q21992447)

Tumour necrosis factor alpha

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

tumor necrosis factor receptor binding

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Characterization of tumor necrosis factor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

protease binding

3 references

IPI

1 reference

9 May 2019

Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cytokine activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

tumor necrosis factor receptor binding

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

13 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Characterization of tumor necrosis factor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cell component

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

1 reference

9 May 2019

membrane raft

3 references

1 reference

9 May 2019

A role for the phagosome in cytokine secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

plasma membrane

secretory granule

1 reference

9 May 2019

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

integral component of plasma membrane

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

phagocytic cup

1 reference

9 May 2019

A role for the phagosome in cytokine secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

intracellular anatomical structure

1 reference

24 April 2018

T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

extracellular space

24 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Negative regulation of Toll-like-receptor signaling by IRF-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Endocrine regulation of energy metabolism by the skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

external side of plasma membrane

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

A role for the phagosome in cytokine secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

1 reference

9 May 2019

cytoplasm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

soma

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

extracellular space

25 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Endocrine regulation of energy metabolism by the skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Negative regulation of Toll-like-receptor signaling by IRF-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cell surface

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of protein phosphorylation

biological process

2 references

9 May 2019

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

MicroRNA-494, Upregulated by Tumor Necrosis Factor-α, Desensitizes Insulin Effect in C2C12 Muscle Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of protein phosphorylation

positive regulation of MAP kinase activity

tumor necrosis factor-mediated signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of JNK cascade

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

response to organic substance

1 reference

9 May 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of osteoblast differentiation

1 reference

9 May 2019

Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

humoral immune response

1 reference

9 May 2019

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

9 May 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

glucose metabolic process

1 reference

9 May 2019

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

animal organ morphogenesis

1 reference

9 May 2019

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

apoptotic signaling pathway

2 references

9 May 2019

Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of alkaline phosphatase activity

1 reference

9 May 2019

Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cell population proliferation

1 reference

24 April 2018

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

activation of cysteine-type endopeptidase activity involved in apoptotic process

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

defense response to Gram-positive bacterium

1 reference

9 May 2019

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of branching involved in salivary gland morphogenesis

negative regulation of myoblast differentiation

1 reference

9 May 2019

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of protein kinase B signaling

1 reference

24 April 2018

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

extrinsic apoptotic signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

osteoclast differentiation

1 reference

9 May 2019

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of transcription, DNA-templated

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

JNK cascade

1 reference

9 May 2019

Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of osteoclast differentiation

1 reference

9 May 2019

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

defense response to bacterium

1 reference

9 May 2019

A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

necroptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

7 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of interleukin-6 production

1 reference

14 February 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

inflammatory response

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Gene from a psoriasis susceptibility locus primes the skin for inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of translational initiation by iron

1 reference

9 May 2019

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of chronic inflammatory response to antigenic stimulus

1 reference

9 May 2019

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of JUN kinase activity

positive regulation of hair follicle development

1 reference

9 May 2019

Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of fever generation

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

extracellular matrix organization

1 reference

9 May 2019

Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of transcription by RNA polymerase II

Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Differential Regulation by Tumor Necrosis Factor-α of β1-, β2-, and β3-Adrenoreceptor Gene Expression in 3T3-F442A Adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

1 reference

9 May 2019

cellular extravasation

1 reference

9 May 2019

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

embryonic digestive tract development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

leukocyte migration

1 reference

9 May 2019

Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

epithelial cell proliferation involved in salivary gland morphogenesis

1 reference

9 May 2019

Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of humoral immune response mediated by circulating immunoglobulin

1 reference

9 May 2019

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of interferon-gamma production

1 reference

9 May 2019

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

multicellular organism development

1 reference

9 May 2019

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of protein-containing complex disassembly

positive regulation of protein-containing complex disassembly

regulation of cell population proliferation

1 reference

1 January 2018

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

positive regulation of cell population proliferation

1 reference

9 May 2019

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of apoptotic process

cellular response to amino acid stimulus

1 reference

9 May 2019

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of I-kappaB kinase/NF-kappaB signaling

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cellular response to lipopolysaccharide

4 references

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

extrinsic apoptotic signaling pathway via death domain receptors

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of transcription by RNA polymerase II

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Differential Regulation by Tumor Necrosis Factor-α of β1-, β2-, and β3-Adrenoreceptor Gene Expression in 3T3-F442A Adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of protein secretion

1 reference

9 May 2019

Regulated renin release from 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of endothelial cell proliferation

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of heterotypic cell-cell adhesion

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of mitotic cell cycle

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of NF-kappaB transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

3 references

8 April 2019

8 April 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

endothelial cell apoptotic process

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

9 May 2019

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of gene expression

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Expression, regulation and functional assessment of the 80 amino acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of inflammatory response

1 reference

9 May 2019

MicroRNA-494, Upregulated by Tumor Necrosis Factor-α, Desensitizes Insulin Effect in C2C12 Muscle Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of NIK/NF-kappaB signaling

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

cell activation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of L-glutamate import across plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

calcium-mediated signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of myelination

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of interleukin-18 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

toll-like receptor 3 signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of neuron apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

positive regulation of action potential

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of mitotic nuclear division

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of synaptic transmission

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06804&geneProductId=UniProtKB:P06804

detection of mechanical stimulus involved in sensory perception of pain

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of gene expression

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

vasodilation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of synapse organization

1 reference

9 May 2019

Synaptic scaling mediated by glial TNF-alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

microglial cell activation

1 reference

9 May 2019

The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

regulation of cell population proliferation

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of fat cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

extrinsic apoptotic signaling pathway via death domain receptors

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of interleukin-6 production

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

tumor necrosis factor-mediated signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of I-kappaB kinase/NF-kappaB signaling

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of transcription by RNA polymerase II

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Differential Regulation by Tumor Necrosis Factor-α of β1-, β2-, and β3-Adrenoreceptor Gene Expression in 3T3-F442A Adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of NF-kappaB transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

4 references

9 May 2019

9 May 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of nitrogen compound metabolic process

1 reference

9 May 2019

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

negative regulation of amyloid-beta clearance

1 reference

9 May 2019

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

positive regulation of amyloid-beta formation

1 reference

9 May 2019

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06804

Tumour necrosis factor domain

has part(s)

1 reference

Tumour necrosis factor, conserved site

1 reference