Interleukin-1 receptor-associated kinase 1 (Q21986041)

Protein kinase-like domain superfamily

1 reference

Death-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Interleukin-1 receptor-associated kinase 1, death domain, protein family

1 reference

Death domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

1 reference

14 February 2019

protein kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Identification and characterization of murine IRAK-M

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

protein serine/threonine kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

protein binding

8 references

14 February 2019

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

interleukin-1 receptor binding

1 reference

14 February 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

heat shock protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

cell component

nucleus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

cytosol

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

response to interleukin-1

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of MAP kinase activity

1 reference

24 April 2018

Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

regulation of cytokine-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

toll-like receptor 4 signaling pathway

1 reference

24 April 2018

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

1 reference

14 February 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

1 reference

14 February 2019

positive regulation of JUN kinase activity

1 reference

14 February 2019

Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

activation of NF-kappaB-inducing kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

response to lipopolysaccharide

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

protein complex oligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

response to peptidoglycan

1 reference

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

protein autophosphorylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Identification and characterization of murine IRAK-M

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

negative regulation of cholesterol efflux

1 reference

14 February 2019

An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

negative regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of type I interferon production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

lipopolysaccharide-mediated signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

1 reference

14 February 2019

type I interferon signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

interleukin-1-mediated signaling pathway

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

24 April 2018

24 April 2018

Identification and characterization of murine IRAK-M

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62406&geneProductId=UniProtKB:Q62406

JNK cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

cellular response to heat

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

cytokine-mediated signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

toll-like receptor 4 signaling pathway

intracellular signal transduction

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of MAP kinase activity

positive regulation of NF-kappaB transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Identification and characterization of murine IRAK-M

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

interleukin-1-mediated signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

14 February 2019

Identification and characterization of murine IRAK-M

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

toll-like receptor 2 signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

innate immune response

The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

cellular response to lipopolysaccharide

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of NIK/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

positive regulation of leukocyte adhesion to vascular endothelial cell

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62406

serine/threonine-protein kinase, active site

has part(s)

1 reference

death domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Interleukin-1 receptor-associated kinase 1, death domain

1 reference