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Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Q21984376)

From Wikidata
mammalian protein found in Mus musculus
  • rocker
  • voltage-gated calcium channel subunit alpha Cav2.1
  • calcium channel, L type, alpha-1 polypeptide
  • BI
  • voltage-dependent P/Q-type calcium channel subunit alpha-1A
  • leaner
  • brain calcium channel I
  • tottering
  • Cacna1a
  • Calcium channel, L type, alpha-1 polypeptide isoform 4
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    English
    Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    mammalian protein found in Mus musculus
    • rocker
    • voltage-gated calcium channel subunit alpha Cav2.1
    • calcium channel, L type, alpha-1 polypeptide
    • BI
    • voltage-dependent P/Q-type calcium channel subunit alpha-1A
    • leaner
    • brain calcium channel I
    • tottering
    • Cacna1a
    • Calcium channel, L type, alpha-1 polypeptide isoform 4

    Statements

    molecular function
    voltage-gated calcium channel activity
    determination method or standard
    ISS
    IDA
    ISO
    IMP
    IEA
    9 references
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P97445
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    ISS
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    ISO
    retrieved
    24 April 2018
    stated in
    Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouseleaner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P97445&geneProductId=UniProtKB:P97445
    determination method or standard
    IDA
    high voltage-gated calcium channel activity
    determination method or standard
    IGI
    IMP
    ISO
    ISS
    12 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P97445
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Whole-Cell and Single-Channel Analysis of P-Type Calcium Currents in Cerebellar Purkinje Cells of Leaner Mutant Mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Characterization of acute somatosensory pain transmission in P/Q‐type Ca2+ channel mutant mice, leaner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Novel Cav2.1 Splice Variants Isolated from Purkinje Cells Do Not Generate P-type Ca2+ Current
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IGI
    voltage-gated calcium channel activity
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    ISO
    ISS
    10 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P97445
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouseleaner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IBA
    cell component
    biological process
    regulation of membrane potential
    determination method or standard
    IMP
    7 references
    retrieved
    14 February 2019
    stated in
    A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouseleaner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    adult walking behavior
    determination method or standard
    IGI
    IMP
    11 references
    retrieved
    14 February 2019
    stated in
    Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance (author's transl)
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P/Q-type Ca2+ channels
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Tottering--a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    L-type calcium channels contribute to the tottering mouse dystonic episodes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IGI
    calcium ion transport
    determination method or standard
    IBA
    IEA
    IMP
    ISO
    6 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouseleaner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P97445
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IBA
    chemical synaptic transmission
    determination method or standard
    IBA
    IMP
    ISO
    5 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97445
    determination method or standard
    IBA

    Identifiers

    RefSeq protein ID
     
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