Eph receptor A8 (Q21981345)

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mammalian protein found in Mus musculus

ephrin type-A receptor 8
Epha8
tyrosine-protein kinase receptor EEK
Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase)
EPH- and ELK-related kinase

Language	Label	Description	Also known as
English	Eph receptor A8	mammalian protein found in Mus musculus	ephrin type-A receptor 8 Epha8 tyrosine-protein kinase receptor EEK Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase) EPH- and ELK-related kinase

Statements

1 reference

25 May 2022

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Galactose-binding-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Sterile alpha motif/pointed domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ephrin receptor

1 reference

based on heuristic

inferred from protein domain or family

Sterile alpha motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ephrin type-A receptor 8, ligand binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase ephrin type A/B receptor-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, receptor class V, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ephrin receptor ligand binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

protein kinase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

GPI-linked ephrin receptor activity

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

protein binding

determination method

5 references

14 February 2019

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

transmembrane receptor protein tyrosine kinase activity

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

protein tyrosine kinase activity

determination method

2 references

determination method

2 references

ephrin receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

transmembrane signaling receptor activity

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

transmembrane-ephrin receptor activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

integral component of membrane

determination method

2 references

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

cell projection

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

early endosome membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

neuron projection

determination method

1 reference

27 March 2018

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

integral component of plasma membrane

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

receptor complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

biological process

regulation of cell adhesion mediated by integrin

determination method

1 reference

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

cellular response to follicle-stimulating hormone stimulus

determination method

1 reference

14 February 2019

The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

neuron remodeling

determination method

1 reference

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

nervous system development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

substrate-dependent cell migration

determination method

1 reference

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

determination method

1 reference

7 November 2018

Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

positive regulation of phosphatidylinositol 3-kinase activity

determination method

1 reference

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

regulation of cell adhesion

determination method

1 reference

14 February 2019

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

protein autophosphorylation

determination method

2 references

peptidyl-tyrosine phosphorylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

neuron projection development

determination method

1 reference

14 February 2019

The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

positive regulation of MAPK cascade

determination method

1 reference

14 February 2019

The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

ephrin receptor signaling pathway

determination method

3 references

14 February 2019

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

14 February 2019

Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09127

determination method

negative regulation of signal transduction

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

cell differentiation

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

negative regulation of apoptotic process

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09127&geneProductId=UniProtKB:O09127

determination method

Ephrin receptor, transmembrane domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

tyrosine-protein kinase ephrin type A/B receptor-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

tyrosine-protein kinase, receptor class V, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

sterile alpha motif domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

ephrin receptor ligand binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Ephrin type-A receptor 8, ligand binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09127

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000030420

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000030420

Sitelinks

Wikipedia(0 entries)

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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