CEA cell adhesion molecule 1 (Q21499241)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31809

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31809

immunoglobulin subtype, protein family

1 reference

Immunoglobulin V-set domain, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

4 references

14 February 2019

CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

14 February 2019

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

14 February 2019

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

14 February 2019

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

virion binding

1 reference

21 June 2018

Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

granulocyte colony-stimulating factor receptor binding

1 reference

14 February 2019

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

actin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

filamin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

Toll-like receptor binding

1 reference

14 February 2019

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

protein phosphatase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

identical protein binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

1 reference

24 April 2018

virus receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

4 references

21 June 2018

21 June 2018

The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

21 June 2018

Purification of the 110-kilodalton glycoprotein receptor for mouse hepatitis virus (MHV)-A59 from mouse liver and identification of a nonfunctional, homologous protein in MHV-resistant SJL/J mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

21 June 2018

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

brush border membrane

1 reference

21 June 2018

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

ciliary membrane

1 reference

14 February 2019

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

external side of plasma membrane

plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

14 February 2019

14 February 2019

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

extracellular space

1 reference

21 June 2018

Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

microvillus membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

adherens junction

basal plasma membrane

apical plasma membrane

lateral plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

biological process

1 reference

21 June 2018

A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

1 reference

21 June 2018

mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

positive regulation of MAP kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

positive regulation of CD4-positive, alpha-beta T cell proliferation

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

positive regulation of JNK cascade

1 reference

14 February 2019

CEACAM1 is a potent regulator of B cell receptor complex-induced activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation by host of viral process

Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

21 June 2018

Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

21 June 2018

Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

negative regulation of JNK cascade

1 reference

21 June 2018

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

positive regulation of CD4-positive, alpha-beta T cell activation

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

negative regulation of T cell proliferation

1 reference

14 February 2019

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

positive regulation of CD8-positive, alpha-beta T cell activation

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

positive regulation by host of viral process

positive regulation of T cell proliferation

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

viral entry into host cell

1 reference

21 June 2018

Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

negative regulation by host of viral genome replication

1 reference

21 June 2018

Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

Peyer's patch development

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

positive regulation of activation-induced cell death of T cells

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of interleukin-2 production

1 reference

21 June 2018

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

negative regulation of cytokine production

1 reference

14 February 2019

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

homophilic cell adhesion via plasma membrane adhesion molecules

1 reference

21 June 2018

Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

negative regulation of interleukin-1 production

1 reference

14 February 2019

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of T cell mediated cytotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

cell-cell junction organization

1 reference

14 February 2019

Ceacam1 deletion causes vascular alterations in large vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of bone resorption

1 reference

14 February 2019

Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

regulation of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

positive regulation of vasculogenesis

1 reference

14 February 2019

Acceleration of Collateral Development by Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Expression on CD11b + /Gr-1 + Myeloid Cells—Brief Report

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

cellular response to insulin stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of vascular permeability

1 reference

14 February 2019

CEACAM1: a key regulator of vascular permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

regulation of cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of granulocyte differentiation

1 reference

14 February 2019

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of platelet aggregation

1 reference

14 February 2019

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

regulation of homophilic cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

regulation of sprouting angiogenesis

1 reference

14 February 2019

Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of protein kinase activity

1 reference

14 February 2019

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

wound healing, spreading of cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

regulation of ERK1 and ERK2 cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of cytotoxic T cell degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

insulin receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

bile acid and bile salt transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of T cell receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

regulation of endothelial cell differentiation

1 reference

14 February 2019

Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

regulation of blood vessel remodeling

1 reference

14 February 2019

Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

regulation of endothelial cell migration

1 reference

14 February 2019

Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

granulocyte colony-stimulating factor signaling pathway

1 reference

14 February 2019

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

common myeloid progenitor cell proliferation

1 reference

14 February 2019

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of fatty acid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

1 reference

14 February 2019

negative regulation of osteoclast differentiation

1 reference

14 February 2019

Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of lipid biosynthetic process

1 reference

14 February 2019

Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

1 reference

14 February 2019

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

blood vessel development

1 reference

14 February 2019

CEACAM1: a key regulator of vascular permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809

positive regulation of calcineurin-NFAT signaling cascade

1 reference

21 June 2018

The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31809&geneProductId=UniProtKB:P31809

viral entry into host cell

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31809