BCL2-like 11 (apoptosis facilitator) (Q21497037)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54918

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Bcl-x interacting, BH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Apoptosis, Bim N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

10 references

8 April 2019

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

dynein complex binding

1 reference

10 October 2017

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

protein heterodimerization activity

1 reference

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

microtubule binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

protein kinase binding

1 reference

8 April 2019

Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

cell component

cytoplasm

1 reference

8 April 2019

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

1 reference

8 April 2019

intracellular membrane-bounded organelle

1 reference

8 April 2019

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

cytoplasmic dynein complex

1 reference

10 October 2017

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

extrinsic component of membrane

1 reference

8 April 2019

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

4 references

10 October 2017

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

microtubule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

BIM-BCL-xl complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

BIM-BCL-2 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

Bcl-2 family protein complex

1 reference

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

mitochondrion

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

biological process

leukocyte homeostasis

male gonad development

1 reference

8 April 2019

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

B cell apoptotic process

1 reference

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

kidney development

1 reference

8 April 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

thymus development

1 reference

8 April 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

lymphocyte homeostasis

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of apoptotic process by virus

1 reference

8 April 2019

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

myeloid cell homeostasis

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

post-embryonic animal organ morphogenesis

1 reference

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

ear development

1 reference

8 April 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

in utero embryonic development

1 reference

8 April 2019

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

B cell homeostasis

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

spleen development

1 reference

8 April 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

post-embryonic development

1 reference

8 April 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

thymocyte apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

response to endoplasmic reticulum stress

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

mammary gland development

1 reference

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of neuron apoptotic process

1 reference

8 April 2019

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

tube formation

1 reference

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

brain development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of cell cycle

1 reference

8 April 2019

Bim regulates BCR-induced entry of B cells into the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of mitochondrial membrane permeability involved in apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

meiosis I

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

1 reference

10 October 2017

spermatogenesis

1 reference

8 April 2019

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

intrinsic apoptotic signaling pathway in response to DNA damage

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of apoptotic process

6 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

developmental pigmentation

1 reference

8 April 2019

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

regulation of developmental pigmentation

1 reference

8 April 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

cell-matrix adhesion

1 reference

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

regulation of organ growth

1 reference

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

apoptotic process involved in embryonic digit morphogenesis

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

1 reference

8 April 2019

positive regulation of cell death

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

regulation of apoptotic process

1 reference

8 April 2019

Polycystic kidney disease prevented by transgenic RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

positive regulation of apoptotic process

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

cellular response to estradiol stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

cellular response to amyloid-beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918

Bcl-x interacting, BH3 domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54918

Apoptosis, Bim N-terminal

1 reference

InterPro Release 71.0